ArticleEnvironmental science and pollution research international2018
Effect of excessive doses of oxytetracycline on stress-related biomarker expression in coho salmon.
Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- Oxidative Stress Biomarkers in Fish Exposed to Environmental Concentrations of Pharmaceutical Pollutants: A Review.Biology · 2025Review
- Longitudinal study on the effects of a synbiotic supplement to Atlantic salmon diets on performance, gut microbiota and immune responses during antibiotic treatment and subsequent recovery.Animal microbiome · 2024Article
- Recent progress in practical applications of a potential carotenoid astaxanthin in aquaculture industry: a review.Fish physiology and biochemistry · 2024Review
- Effects of Red Yeast (Sporidiobolus pararoseus) on Growth, Innate Immunity, Expression of Immune-related Genes and Disease Resistance of Nile Tilapia (Oreochromis niloticus).Probiotics and antimicrobial proteins · 2023Article
- Growth Performance, Antioxidant and Immunity Capacity Were Significantly Affected by Feeding Fermented Soybean Meal in Juvenile Coho Salmon (Animals : an open access journal from MDPI · 2023Article
- Evaluation of Fermented Soybean Meal to Replace a Portion Fish Meal on Growth Performance, Antioxidant Capacity, Immunity, and mTOR Signaling Pathway of Coho Salmon (Aquaculture nutrition · 2023Article
- Research Progress of the Gut Microbiome in Hybrid Fish.Microorganisms · 2022Review
- The ameliorative role of ascorbic acid against blood disorder, immunosuppression, and oxidative damage of oxytetracycline in rainbow trout (Oncorhynchus mykiss).Fish physiology and biochemistry · 2022Article
- Antibiotic accumulation, growth performance, intestinal diversification, and function of Nile tilapia (Oreochromis niloticus) feed by diets supplemented with different doses of sulfamethoxazole.Environmental science and pollution research international · 2021Article
- Review
- Effects of Oxytetracycline and Gentamicin Therapeutic Doses on Hematological, Biochemical and Hematopoietic Parameters inAnimals : an open access journal from MDPI · 2020Article
- Properties of Carotenoids in Fish Fitness: A Review.Marine drugs · 2020Review
- Antibacterials in Aquatic Environment and Their Toxicity to Fish.Pharmaceuticals (Basel, Switzerland) · 2020Review
- The Effect of Acute Erythromycin Exposure on the Swimming Ability of Zebrafish (International journal of environmental research and public health · 2020Article
- Spatial overlap of shark nursery areas and the salmon farming industry influences the trophic ecology ofEcology and evolution · 2017Article
- Rainbow trout (Oncorhynchus mykiss) pro-oxidant and genotoxic responses following acute and chronic exposure to the antibiotic oxytetracycline.Ecotoxicology (London, England) · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fish are exposed to a wide variety of environmental stressors, such as chemicals and acute changes in temperature. Oxytetracycline (OTC) has been used as an antibiotic for many kinds of bacterial diseases in cultured fish, but excessive doses of OTC are known to cause side effects in fish and can have negative effects on their environment. In the present study, we examined stress-related biomarker expression in response to excessive doses of dietary OTC in coho salmon (Oncorhynchus kisutch). Fish received OTC (100 mg/kg body weight/day) orally for 2 weeks. The percentage of liver to body weight (hepatosomatic index; HSI) and plasma biochemical parameter, alanine aminotransferase (ALT) activity, of the group fed a diet containing OTC were observed to be significantly higher than those of the control group. The total glutathione (tGSH) levels in the liver of OTC-fed fish were four fold higher than those in control fish and double the control levels in muscle and stomach. Plasma tGSH levels in OTC-fed fish were also higher than those in control fish. Expression levels of heat shock protein 70 in the liver, muscle, and stomach decreased by OTC administration. Accordingly, OTC-induced stress might increase the metabolic turnover of GSH due to consumption by scavenging oxidants generated by stress. These results concerning the changing patterns of stress-related biomarkers indicate that excessive doses of OTC fed to coho salmon induce oxidative stress, which might enhance oxidation in the body and result in damage to tissues, especially in the liver. The present results also suggest that tissue-specific damage caused by OTC might already exist in fish.
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