ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Emotion Regulatory Brain Function and SSRI Treatment in PTSD: Neural Correlates and Predictors of Change.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Emotion regulation impairment across psychiatric disorders: a systematic review and meta-analysis.Translational psychiatry · 2026Pooled it
- Fears Worth Testing Out: A Systematic Review of the Neural Mechanisms of Treatment Outcome for Anxiety-Related Disorders.Current topics in behavioral neurosciences · 2025Pooled it
- Does non-invasive brain stimulation modulate emotional stress reactivity?Social cognitive and affective neuroscience · 2020Pooled it
- Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.Psychiatry research. Neuroimaging · 2024Trial
- Within-patient association between emotion regulation and outcome in prolonged exposure for posttraumatic stress disorder.Journal of consulting and clinical psychology · 2024Trial
- Brain-behavioral adaptability predicts response to cognitive behavioral therapy for emotional disorders: A person-centered event-related potential study.Neuropsychologia · 2020Trial
- Neural correlates of emotional reactivity and regulation associated with treatment response in a randomized clinical trial for posttraumatic stress disorder.Psychiatry research. Neuroimaging · 2020Trial
- Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Integrated proteomic and metabolomic analyses implicate redox-metabolic pathways in PTSD-associated multisystem disease and accelerated aging.Nature communications · 2026Article
- Dissociative symptom trajectories during treatment with selective serotonin reuptake inhibitors for depressive or anxiety disorders.BMC psychiatry · 2026Observational
- A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder.Journal of affective disorders reports · 2026Article
- Neural predictors of treatment outcome through emotion regulation in internalizing disorders: a narrative review.Translational psychiatry · 2026Review
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neural indices of cognitive reappraisal impact the association between childhood trauma and suicide risk in adulthood.Psychiatry research. Neuroimaging · 2025Article
- The impact of neural emotion reactivity and regulation on the association between depression and suicide ideation in high-risk adults.Journal of affective disorders · 2024Article
- Integrating dynamic psychophysiological indices across time and contexts: Elucidating mechanisms, risk markers, and intervention targets.Psychophysiology · 2024Review
- Survival, Attachment, and Healing: An Evolutionary Lens on Interventions for Trauma-Related Dissociation.Psychology research and behavior management · 2024Review
- Temporal sequencing of change in trauma-related beliefs and therapeutic alliance during prolonged exposure and sertraline for chronic PTSD.Psychotherapy research : journal of the Society for Psychotherapy Research · 2024Article
- Neural correlates of PTSD in women with childhood sexual abuse with and without PTSD and response to paroxetine treatment: A placebo-controlled, double-blind trial.Journal of affective disorders reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD)-a chronic, debilitating condition, broadly characterized by emotion dysregulation-is prevalent among US military personnel who have returned from Operations Enduring Freedom (OEF) and Iraqi Freedom (OIF). Selective serotonin reuptake inhibitors (SSRIs) are a first-line treatment for PTSD, but treatment mechanisms are unknown and patient response varies. SSRIs may exert their effects by remediating emotion regulatory brain activity and individual differences in patient response might be explained, in part, by pre-treatment differences in neural systems supporting the downregulation of negative affect. Thirty-four OEF/OIF veterans, 17 with PTSD and 17 without PTSD underwent 2 functional magnetic resonance imaging scans 12 weeks apart. At each scan, they performed an emotion regulation task; in the interim, veterans with PTSD were treated with the SSRI, paroxetine. SSRI treatment increased activation in both the left dorsolateral prefrontal cortex (PFC) and supplementary motor area (SMA) during emotion regulation, although only change in the SMA over time occurred in veterans with PTSD and not those without PTSD. Less activation of the right ventrolateral PFC/inferior frontal gyrus during pre-treatment emotion regulation was associated with greater reduction in PTSD symptoms with SSRI treatment, irrespective of pre-treatment severity. Patients with the least recruitment of prefrontal emotion regulatory brain regions may benefit most from treatment with SSRIs, which appear to augment activity in these regions.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.