ArticleBJOG : an international journal of obstetrics and gynaecology2015
Maternal characteristics and mid-pregnancy serum biomarkers as risk factors for subtypes of preterm birth.
Article in BJOG : an international journal of obstetrics and gynaecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Is there a maternal blood biomarker that can predict spontaneous preterm birth prior to labour onset? A systematic review.PloS one · 2022Pooled it
- Short interpregnancy intervals and adverse perinatal outcomes in high-resource settings: An updated systematic review.Paediatric and perinatal epidemiology · 2019Pooled it
- First trimester prenatal screening biomarkers and gestational diabetes mellitus: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Depressive symptoms and gestational length among pregnant adolescents: Cluster randomized control trial of CenteringPregnancy® plus group prenatal care.Journal of consulting and clinical psychology · 2017Trial
- Dynamics of Cytokines and Chemokines During the Peripartum Period in People Living With Human Immunodeficiency Virus.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Observational
- Adverse pregnancy outcomes across SLE subgroups: significance of cardiovascular events.Lupus science & medicine · 2025Article
- Pre-conception clinical risk factors differ between spontaneous and indicated preterm birth in a densely phenotyped EHR cohort.BMC pregnancy and childbirth · 2025Article
- Cardiovascular Events During Pregnancy: Implications for Adverse Pregnancy Outcomes in Individuals With Autoimmune and Rheumatic Diseases.The Journal of rheumatology · 2025Article
- The University of California Study of Outcomes in Mothers and Infants (a Population-Based Research Resource): Retrospective Cohort Study.JMIR public health and surveillance · 2024Article
- Risk and Protective Factors for Preterm Birth Among Racial, Ethnic, and Socioeconomic Groups in California.JAMA network open · 2024Article
- Article
- Assessing for prenatal risk factors associated with infant neurologic morbidity using a multivariate analysis.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Association of Gestational Hypertension with Sociodemographic and Anthropometric Factors, Perinatal Outcomes, Breastfeeding Practices, and Mediterranean Diet Adherence: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2023Article
- Firearm Injuries during Pregnancy in the USA.Clinics and practice · 2023Article
- Epidemiology of Adverse Outcomes in Teenage Pregnancy-A Northeastern Romanian Tertiary Referral Center.International journal of environmental research and public health · 2023Article
- Placental protein levels in maternal serum are associated with adverse pregnancy outcomes in nulliparous patients.American journal of obstetrics and gynecology · 2022Article
- Benzene and NOInternational journal of environmental research and public health · 2022Article
- Routine first-trimester pre-eclampsia screening and risk of preterm birth.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022Article
- Association Between Serum Markers Used in the Routine Prenatal Screening with Pregnancy Outcomes: A Cohort Study.Journal of obstetrics and gynaecology of India · 2022Article
- Interpregnancy Interval and Birth Outcomes: A Propensity Matching Study in the California Population.Maternal and child health journal · 2022Article
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Funding
Abstract
objectiveTo examine the relationship between maternal characteristics, serum biomarkers and preterm birth (PTB) by spontaneous and medically indicated subtypes.
designPopulation-based cohort.
settingCalifornia, United States of America. POPULATION: From a total population of 1 004 039 live singleton births in 2009 and 2010, 841 665 pregnancies with linked birth certificate and hospital discharge records were included.
methodsCharacteristics were compared for term and preterm deliveries by PTB subtype using logistic regression and odds ratios adjusted for maternal characteristics and obstetric factors present in final stepwise models and 95% confidence intervals. First-trimester and second-trimester serum marker levels were analysed in a subset of 125 202 pregnancies with available first-trimester and second-trimester serum biomarker results.
main outcome measurePTB by subtype.
resultsIn fully adjusted models, ten characteristics and three serum biomarkers were associated with increased risk in each PTB subtype (Black race/ethnicity, pre-existing hypertension with and without pre-eclampsia, gestational hypertension with pre-eclampsia, pre-existing diabetes, anaemia, previous PTB, one or two or more previous caesarean section(s), interpregnancy interval ≥ 60 months, low first-trimester pregnancy-associated plasma protein A, high second-trimester α-fetoprotein, and high second-trimester dimeric inhibin A). These risks occurred in 51.6-86.2% of all pregnancies ending in PTB depending on subtype. The highest risk observed was for medically indicated PTB <32 weeks in women with pre-existing hypertension and pre-eclampsia (adjusted odds ratio 89.7, 95% CI 27.3-111.2).
conclusionsOur findings suggest a shared aetiology across PTB subtypes. These commonalities point to targets for further study and exploration of risk reduction strategies. TWEETABLE ABSTRACT: Findings suggest a shared aetiology across preterm birth subtypes. Patterns may inform risk reduction efforts.
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