ArticleNeuropsychologia2015
Sex-related functional asymmetry of the ventromedial prefrontal cortex in regard to decision-making under risk and ambiguity.
Article in Neuropsychologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Sex differences in maturational timing of amygdala and prefrontal cortex volumes and white matter tract microstructure.Developmental cognitive neuroscience · 2025Article
- Distinct neural networks of task engagement and choice response in moral, risky, and ambiguous decision-making: An ALE meta-analysis.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Molecular laterality encodes stress susceptibility in the medial prefrontal cortex.Molecular brain · 2021Article
- Risk-taking bias in human decision-making is encoded via a right-left brain push-pull system.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Let's call the whole thing off: evaluating gender and sex differences in executive function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Contributions of medial prefrontal cortex to decision making involving risk of punishment.Neuropharmacology · 2018Article
- Sex differences in the functional lateralization of emotion and decision making in the human brain.Journal of neuroscience research · 2017Review
- Sex-Differences, Handedness, and Lateralization in the Iowa Gambling Task.Frontiers in psychology · 2016Article
- Sex and HIV serostatus differences in decision making under risk among substance-dependent individuals.Journal of clinical and experimental neuropsychology · 2016Article
- Reward processing and drug addiction: does sex matter?Frontiers in neuroscience · 2015Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Previous work has provided preliminary indication of sex-related functional asymmetry of the ventromedial prefrontal cortex (vmPFC) in social and emotional functions and complex decision-making. Findings have been inconsistent, and based on small numbers of patients. Given the rarity of these neurological cases, replicable results across studies are important to build evidence for sex-related functional asymmetry of the vmPFC. Here we used a sample of sixteen neurological patients with unilateral damage to the left or right vmPFC and examined differences between men and women on a task that probed decision-making under risk or decision-making under ambiguity. We found that men with right-hemisphere vmPFC damage and women with left-hemisphere vmPFC damage demonstrated significantly reduced aversion to risk and ambiguity. Men with damage to the left vmPFC and women with damage to the right vmPFC showed aversion to risk and ambiguity comparable to participants with left or right-sided brain damage outside the vmPFC, and to comparison participants without brain damage. Our results add to previous findings of sex-related functional asymmetry of the vmPFC in decision-making. Our study also replicates findings of no observable behavioral differences between men and women without neurological damage on tests of decision-making. This pattern of neurobiological divergence but behavioral convergence between men and women may reflect a complex interplay of neuroendocrine, developmental, and psychosocial factors.
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