Evidence map›Paper›PMID 26111443›Full record

ArticlePaediatric and perinatal epidemiology2015

Newborn Adipokines and Birth Outcomes.

Edwina H Yeung, Alexander C McLain, Nancy Anderson, David Lawrence, Nansi S Boghossian, Charlotte Druschel, Erin Bell

Open access · greenAbstract read
In one paragraph

Article in Paediatric and perinatal epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
12.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

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  11. Comparison of selected body composition parameters in women using DXA and anthropometric method.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019
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  17. Maternal Smoking and Newborn Cytokine and Immunoglobulin Levels.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017
    Article
  18. Relationship of maternal birth weight on maternal and neonatal outcomes: a multicenter study in Beijing.Journal of perinatology : official journal of the California Perinatal Association · 2016
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Edwina H YeungEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.ORCID http://orcid.org/0000-0002-3851-2613
Alexander C McLainEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Nancy AndersonLaboratory of Immunology, Wadsworth Center, Center for Medical Science, Albany, NY.
David LawrenceLaboratory of Immunology, Wadsworth Center, Center for Medical Science, Albany, NY.
Nansi S BoghossianEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Charlotte DruschelBureau of Environmental and Occupational Epidemiology, Center for Environmental Health, New York State Department of Health, Albany, NY.
Erin BellDepartment of Environmental Health Sciences, University at Albany School of Public Health, Albany, NY.
University of South Carolina · USWadsworth Center · USAlbany College of Pharmacy and Health Sciences · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNew York State Department of Health · US

Funding

Infertility Treatment, Child Growth and Development Through Age Three YearsZIAHD008826 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YEUNG, EDWINA · 2009 to 2025
$9.4M
Developmental Infrastructure CoreR24HD044943 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI SHAW, BENJAMIN A · 2004 to 2016
$4.8M
Intramural NIH HHSNICHD NIH HHS HHSN267200700019CNICHD NIH HHS HHSN275201200005CNICHD NIH HHS R24 HD044943PHS HHS HHSN267200700019CPHS HHS HHSN275201200005C
6 · The paper itself

Abstract

backgroundAdipokines can serve as a measure of adipose tissue activity. Although birthweight correlates with neonatal adiposity, findings for cord blood levels of adipokines and birth outcomes have been conflicted. Therefore, we determined the cross-sectional associations between adipokines measured in newborn dried blood spots (DBS) and birth outcomes.

methodsThe Upstate KIDS study enrolled mothers and infants from 2008 to 2010. Among infants whose parents consented to the use of residual DBS from newborn screening, 2397 singletons and 1240 twins had adipokine measurements from the Human Obesity Panel (R&D Systems) by Luminex. Odds ratios were estimated by multivariable logistic regression for risk of birth outcomes of preterm delivery (<37 weeks for singletons, <32 for twins) and small-for-gestational age (SGA <10th for singletons and <3rd for twins age- and sex-specific percentiles) by adipokine quintiles. Generalised estimating equations were applied to account for correlations between twins.

resultsSingletons in the lowest compared with the highest quintile of adiponectin were more likely preterm (adjusted odds ratio 3.26; 95% confidence interval [CI] 1.99, 5.34) and SGA (1.81; [95% CI 1.18, 2.77]). Similar associations were observed among twins. Resistin was associated with preterm birth (Q1 vs. Q5: 2.08; [95% CI 1.20, 3.62]) only among singletons. Adipsin had inconsistent associations after adjustment.

conclusionsThis large population-based study demonstrates that newborn DBS-measured adipokines are associated with birth outcomes, particularly preterm birth and SGA among those with lower adiponectin levels regardless of plurality.

Indexed as

AdiposityDried Blood Spot TestingAdipokinesAdultBirth WeightCross-Sectional StudiesFemaleFetal Growth RetardationGestational AgeHumansInfant, NewbornInfant, PrematureInfant, Small for Gestational AgeMalePredictive Value of TestsPregnancyAdipokinesResistinadiponectinbirth weightleptinnewborn dried blood spotspreterm birthtwins

Identifiers

PMID26111443
PMCPMC4484786
OpenAlexW1548396511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.