ArticlePloS one2015
Exercise Improves Host Response to Influenza Viral Infection in Obese and Non-Obese Mice through Different Mechanisms.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
- Sex Differences in the Impact of Obesity on Immunity.Immunological reviews · 2026Review
- An Overview of the Effects of Exercise on Viral Infection in Obesity: Recent Advances and Potential Mechanisms.Applied biochemistry and biotechnology · 2026Review
- Biological sex differences after high and low doses of influenza A virus infection during obesity.Frontiers in immunology · 2026Article
- Modulating CD8⁺ T cell immunity through exercise: mechanistic insights and implications for precision immunotherapy.Theranostics · 2026Review
- Age, lifestyle, and disease affect ciliary transport in the human fallopian tube.Scientific reports · 2025Article
- Biological Sex Differences after High and Low Doses of Influenza A Virus Infection in a Diet-induced Obesity Mouse Model.bioRxiv : the preprint server for biology · 2025Article
- Body Size and Risk of Death During the 1918 Influenza Pandemic in Alaska.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Role of Physical Activity in the Prevention and Treatment of Influenza: A Review.Sports medicine - open · 2023Review
- The role of TLR2 in exercise-induced immunomodulation in normal weight individuals.Scientific reports · 2023Article
- Synchronous and asynchronous tele-exercise during the coronavirus disease 2019 pandemic: Comparisons of implementation and training load in individuals with spinal cord injury.Journal of telemedicine and telecare · 2023Article
- Obesity and Leptin Resistance in the Regulation of the Type I Interferon Early Response and the Increased Risk for Severe COVID-19.Nutrients · 2022Review
- Effects of physical activity on the severity of illness and mortality in COVID-19 patients: A systematic review and meta-analysis.Frontiers in physiology · 2022Article
- Obesity, a major risk factor for immunity and severe outcomes of COVID-19.Bioscience reports · 2021Review
- The impact of COVID-19 lockdown on physical activity and weight gain among active adult population in Israel: a cross-sectional study.BMC public health · 2021Article
- Neutralization of IL-33 modifies the type 2 and type 3 inflammatory signature of viral induced asthma exacerbation.Respiratory research · 2021Article
- Susceptibility and Severity of Viral Infections in Obesity: Lessons from Influenza to COVID-19. Does Leptin Play a Role?International journal of molecular sciences · 2021Review
- Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections.Frontiers in immunology · 2021Review
- Molecular mechanisms involved in the positive effects of physical activity on coping with COVID-19.European journal of applied physiology · 2020Review
- Article
- Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients.Biology · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Obesity has been associated with greater severity of influenza virus infection and impaired host defense. Exercise may confer health benefits even when weight loss is not achieved, but it has not been determined if regular exercise improves immune defense against influenza A virus (IAV) in the obese condition. In this study, diet-induced obese mice and lean control mice exercised for eight weeks followed by influenza viral infection. Exercise reduced disease severity in both obese and non-obese mice, but the mechanisms differed. Exercise reversed the obesity-associated delay in bronchoalveolar-lavage (BAL) cell infiltration, restored BAL cytokine and chemokine production, and increased ciliary beat frequency and IFNα-related gene expression. In non-obese mice, exercise treatment reduced lung viral load, increased Type-I-IFN-related gene expression early during infection, but reduced BAL inflammatory cytokines and chemokines. In both obese and non-obese mice, exercise increased serum anti-influenza virus specific IgG2c antibody, increased CD8+ T cell percentage in BAL, and reduced TNFα by influenza viral NP-peptide-responding CD8+ T cells. Overall, the results suggest that exercise "restores" the immune response of obese mice to a phenotype similar to non-obese mice by improving the delay in immune activation. In contrast, in non-obese mice exercise treatment results in an early reduction in lung viral load and limited inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.