ArticleViruses2015
The Effect of Oral Administration of dsRNA on Viral Replication and Mortality in Bombus terrestris.
Article in Viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Occurrence of Honey Bee (Frontiers in cellular and infection microbiology · 2022Article
- Pathogens Spillover from Honey Bees to Other Arthropods.Pathogens (Basel, Switzerland) · 2021Review
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- Self-Powered Smart Beehive Monitoring and Control System (SBMaCS).Sensors (Basel, Switzerland) · 2021Article
- Article
- Possible Spillover of Pathogens between Bee Communities Foraging on the Same Floral Resource.Insects · 2021Article
- Chemical Stimulants and Stressors Impact the Outcome of Virus Infection and Immune Gene Expression in Honey Bees (Frontiers in immunology · 2021Article
- RNAi-Based Biocontrol Products: Market Status, Regulatory Aspects, and Risk Assessment.Frontiers in insect science · 2021Article
- The Honey Bee GeneFrontiers in insect science · 2021Article
- Identification and temporal expression profiles of cuticular proteins in the endoparasitoid wasp, Microplitis mediator.Insect science · 2020Article
- Article
- Targeting genes involved in nucleopolyhedrovirus DNA multiplication through RNA interference technology to induce resistance against the virus in silkworms.Molecular biology reports · 2020Article
- Article
- Bee Viruses: Routes of Infection in Hymenoptera.Frontiers in microbiology · 2020Review
- Assessing the Risks of Topically Applied dsRNA-Based Products to Non-target Arthropods.Frontiers in plant science · 2020Article
- The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.The EMBO journal · 2019Article
- Double-stranded RNA reduces growth rates of the gut parasite Crithidia mellificae.Parasitology research · 2019Article
- Management of Pest Insects and Plant Diseases by Non-Transformative RNAi.Frontiers in plant science · 2019Review
- Leishmania, microbiota and sand fly immunity.Parasitology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Israeli acute paralysis virus (IAPV), a single-stranded RNA virus, has a worldwide distribution and affects honeybees as well as other important pollinators. IAPV infection in honeybees has been successfully repressed by exploiting the RNA interference (RNAi) pathway of the insect's innate immune response with virus-specific double stranded RNA (dsRNA). Here we investigated the effect of IAPV infection in the bumblebee Bombus terrestris and its tissue tropism. B. terrestris is a common pollinator of wild flowers in Europe and is used for biological pollination in agriculture. Infection experiments demonstrated a similar pathology and tissue tropism in bumblebees as reported for honeybees. The effect of oral administration of virus-specific dsRNA was examined and resulted in an effective silencing of the virus, irrespective of the length. Interestingly, we observed that non-specific dsRNA was also efficient against IAPV. However further study is needed to clarify the precise mechanism behind this effect. Finally we believe that our data are indicative of the possibility to use dsRNA for a broad range viral protection in bumblebees.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.