Evidence map›Paper›PMID 26110578›Full record

ArticleJournal of personalized medicine2015

Phenotype-Driven Plasma Biobanking Strategies and Methods.

Erica A Bowton, Sarah P Collier, Xiaoming Wang, Cara B Sutcliffe, Sara L Van Driest, Lindsay J Couch, Miguel Herrera, Rebecca N Jerome, Robbert J C Slebos, William E Alborn and 7 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of personalized medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05277116 (The Electronic Medical Records and GEnomics), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05277116 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

The Electronic Medical Records and GEnomics (eMERGE) Network Genomic Risk Assessment

TypeinterventionalSponsorVanderbilt University Medical CenterRan2022 to 2030Enrolled26,877ConditionsGenetic DiseaseArmsGenome Informed Risk Assessment (GIRA) report
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. High-throughput phenotyping with temporal sequences.Journal of the American Medical Informatics Association : JAMIA · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Erica A BowtonInstitute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. erica.a.bowton@vanderbilt.edu.
Sarah P CollierInstitute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. sarah.p.collier@vanderbilt.edu.
Xiaoming WangInstitute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. sunny.wang@vanderbilt.edu.
Cara B SutcliffeVanderbilt Technologies for Advanced Genomics Core Facility, Vanderbilt University, Nashville, TN 37232, USA. cara.b.sutcliffe@vanderbilt.edu.
Sara L Van DriestDepartments of Pediatrics and Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. sara.van.driest@vanderbilt.edu.
Lindsay J CouchVanderbilt Technologies for Advanced Genomics Core Facility, Vanderbilt University, Nashville, TN 37232, USA. lindsayjcouch@gmail.com.
Miguel HerreraVanderbilt Technologies for Advanced Genomics Core Facility, Vanderbilt University, Nashville, TN 37232, USA. miguel.herrera@vanderbilt.edu.
Rebecca N JeromeInstitute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. rebecca.jerome@vanderbilt.edu.
Robbert J C SlebosJim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt University, Nashville, TN 37232, USA. r.slebos@vanderbilt.edu.
William E AlbornJim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt University, Nashville, TN 37232, USA. william.alborn@vanderbilt.edu.
Daniel C LieblerJim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt University, Nashville, TN 37232, USA. daniel.liebler@vanderbilt.edu.
Candace D McNaughtonDepartment of Emergency Medicine, Vanderbilt University, Nashville, TN 37232, USA. candace.mcnaughton@vanderbilt.edu.
Ray L MernaughDepartment of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA. r.mernaugh@vanderbilt.edu.
Quinn S WellsDepartments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. quinn.s.wells@vanderbilt.edu.
Nancy J BrownDepartments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. nancy.j.brown@vanderbilt.edu.
Dan M RodenDepartments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. dan.roden@vanderbilt.edu.
Jill M PulleyInstitute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. jill.pulley@vanderbilt.edu.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The Vanderbilt Emergency Medicine Research Training Program (VEMRT)K12HL109019 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COLLINS, SEAN PATRICK, STORROW, ALAN B · 2011 to 2015
$3.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)KL2TR000446 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$2.8M
A Randomized, ED-based Intervention to Improve Antihypertensive AdherenceK23HL125670 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MCNAUGHTON, CANDACE · 2015 to 2017
$488k
BioVU Plasma Storage EquipmentS10OD017985 · OD · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2014 to 2014
$239k
NCATS NIH HHS KL2 TR000446NCATS NIH HHS UL1 TR000445NHLBI NIH HHS K12 HL109019NHLBI NIH HHS K23 HL125670NIH HHS S10 OD017985
6 · The paper itself

Abstract

Biobank development and integration with clinical data from electronic medical record (EMR) databases have enabled recent strides in genomic research and personalized medicine. BioVU, Vanderbilt's DNA biorepository linked to de-identified clinical EMRs, has proven fruitful in its capacity to extensively appeal to numerous areas of biomedical and clinical research, supporting the discovery of genotype-phenotype interactions. Expanding on experiences in BioVU creation and development, we have recently embarked on a parallel effort to collect plasma in addition to DNA from blood specimens leftover after routine clinical testing at Vanderbilt. This initiative offers expanded utility of BioVU by combining proteomic and metabolomic approaches with genomics and/or clinical outcomes, widening the breadth for potential research and subsequent future impact on clinical care. Here, we describe the considerations and components involved in implementing a plasma biobank program from a feasibility assessment through pilot sample collection.

Indexed as

biobankingbiorepositoryBioVUplasmaproteomics

Identifiers

PMID26110578
PMCPMC4493492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.