ArticlePloS one2015
Mitochondrial DNA copy number in peripheral blood and melanoma risk.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered mitochondrial DNA copy number contributes to human cancer risk: evidence from an updated meta-analysis.Scientific reports · 2016Pooled it
- Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans.PloS one · 2019Trial
- Longevity cosmeceuticals as the next frontier in cosmetic innovation: a scientific framework for substantiating product claims.Frontiers in aging · 2025Review
- The role of mitochondria in the resistance of melanoma to PD-1 inhibitors.Journal of translational medicine · 2023Review
- Insights regarding mitochondrial DNA copy number alterations in human cancer (Review).International journal of molecular medicine · 2022Review
- Review
- Mitochondrial DNA copy number in human disease: the more the better?FEBS letters · 2021Review
- Mitochondrial DNA Copy Number in Peripheral Blood as a Potential Non-invasive Biomarker for Multiple Sclerosis.Neuromolecular medicine · 2020Article
- Mitochondrial DNA copy number is associated with all-cause mortality and cardiovascular events in patients with peripheral arterial disease.Journal of internal medicine · 2020Article
- Lifestyle and behavioral factors and mitochondrial DNA copy number in a diverse cohort of mid-life and older adults.PloS one · 2020Article
- Predictors of mitochondrial DNA copy number and damage in a mercury-exposed rural Peruvian population near artisanal and small-scale gold mining: An exploratory study.Environmental and molecular mutagenesis · 2019Article
- Mitochondrial DNA copy number in peripheral blood: a potential non-invasive biomarker for female subfertility.Journal of assisted reproduction and genetics · 2018Article
- Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort.Epigenomics · 2018Article
- Mitochondrial DNA copy number in peripheral blood cell and hypertension risk among mining workers: a case-control study in Chinese coal miners.Journal of human hypertension · 2017Article
- MtDNA As a Cancer Marker: A Finally Closed Chapter?Current genomics · 2017Review
- Global methylation of blood leukocyte DNA and risk of melanoma.International journal of cancer · 2017Article
- Pre-diagnostic leukocyte mitochondrial DNA copy number and skin cancer risk.Carcinogenesis · 2016Article
- Mitochondrial DNA 4977-base pair common deletion in blood leukocytes and melanoma risk.Pigment cell & melanoma research · 2016Article
- Peripheral blood mitochondrial DNA copy number, length heteroplasmy and breast cancer risk: a replication study.Carcinogenesis · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Mitochondrial DNA (mtDNA) copy number in peripheral blood has been suggested as risk modifier in various types of cancer. However, its influence on melanoma risk is unclear. We evaluated the association between mtDNA copy number in peripheral blood and melanoma risk in 500 melanoma cases and 500 healthy controls from an ongoing melanoma study. The mtDNA copy number was measured using real-time polymerase chain reaction. Overall, mean mtDNA copy number was significantly higher in cases than in controls (1.15 vs 0.99, P<0.001). Increased mtDNA copy number was associated with a 1.45-fold increased risk of melanoma (95% confidence interval: 1.12-1.97). Significant joint effects between mtDNA copy number and variables related to pigmentation and history of sunlight exposure were observed. This study supports an association between increased mtDNA copy number and melanoma risk that is independent on the known melanoma risk factors (pigmentation and history of sunlight exposure).
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