ArticlePloS one2015
Intrinsic functional plasticity of the sensorimotor network in relapsing-remitting multiple sclerosis: evidence from a centrality analysis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Abnormal Intrinsic Functional Hubs in Severe Male Obstructive Sleep Apnea: Evidence from a Voxel-Wise Degree Centrality Analysis.PloS one · 2016Trial
- Spatial gene expression and functional network abnormalities in multiple sclerosis: exploring biological influence on brain functional reorganization.Translational psychiatry · 2026Article
- Complexity of intrinsic brain activity in relapsing-remitting multiple sclerosis patients: patterns, association with structural damage, and clinical disability.La Radiologia medica · 2025Observational
- Abnormal functional hubs in migraine patients: a resting-state MRI analysis about voxel-wise degree centrality.Journal of oral & facial pain and headache · 2024Article
- Male and female are not the same: a multicenter study of static and dynamic functional connectivity in relapse-remitting multiple sclerosis in China.Frontiers in immunology · 2023Article
- Aberrant degree centrality of functional brain networks in subclinical depression and major depressive disorder.Frontiers in psychiatry · 2023Article
- Observational
- Spectral signatures of mirror movements in the sensori-motor connectivity in kallmann syndrome.Human brain mapping · 2018Article
- Frequency-Specific Abnormalities of Intrinsic Functional Connectivity Strength among Patients with Amyotrophic Lateral Sclerosis: A Resting-State fMRI Study.Frontiers in aging neuroscience · 2017Article
- White and Gray Matter Volume Changes and Correlation with Visual Evoked Potential in Patients with Optic Neuritis: A Voxel-Based Morphometry Study.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study.Frontiers in human neuroscience · 2016Article
- Delineation of cortical pathology in multiple sclerosis using multi-surface magnetization transfer ratio imaging.NeuroImage. Clinical · 2016Article
- Identifying the Alteration Patterns of Brain Functional Connectivity in Progressive Mild Cognitive Impairment Patients: A Longitudinal Whole-Brain Voxel-Wise Degree Analysis.Frontiers in aging neuroscience · 2016Article
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3 authors.
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Abstract
background and purposeAdvanced MRI studies have revealed regional alterations in the sensorimotor cortex of patients with relapsing-remitting multiple sclerosis (RRMS). However, the organizational features underlying the relapsing phase and the subsequent remitting phase have not been directly shown at the functional network or the connectome level. Therefore, this study aimed to characterize MS-related centrality disturbances of the sensorimotor network (SMN) and to assess network integrity and connectedness.
methodsThirty-four patients with clinically definite RRMS and well-matched healthy controls participated in the study. Twenty-three patients in the remitting phase underwent one resting-state functional MRI, and 11 patients in the relapsing-remitting phase underwent two different MRIs. We measured voxel-wise centrality metrics to determine direct (degree centrality, DC) and global (eigenvector centrality, EC) functional relationships across the entire SMN.
resultsIn the relapsing phase, DC was significantly decreased in the bilateral primary motor and somatosensory cortex (M1/S1), left dorsal premotor (PMd), and operculum-integrated regions. However, DC was increased in the peripheral SMN areas. The decrease in DC in the bilateral M1/S1 was associated with the expanded disability status scale (EDSS) and total white matter lesion loads (TWMLLs), suggesting that this adaptive response is related to the extent of brain damage in the rapid-onset attack stage. During the remission process, these alterations in centrality were restored in the bilateral M1/S1 and peripheral SMN areas. In the remitting phase, DC was reduced in the premotor, supplementary motor, and operculum-integrated regions, reflecting an adaptive response due to brain atrophy. However, DC was enhanced in the right M1 and left parietal-integrated regions, indicating chronic reorganization. In both the relapsing and remitting phases, the changes in EC and DC were similar.
conclusionsThe alterations in centrality within the SMN indicate rapid plasticity and chronic reorganization with a biased impairment of specific functional areas in RRMS patients.
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