ReviewGenes2015
Hedgehog Signaling during Appendage Development and Regeneration.
Review in Genes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Centrosome-Signaling Pathway Crosstalk: A Core Hub From Cellular Homeostasis to Disease.Cytoskeleton (Hoboken, N.J.) · 2026Review
- Wnt5a regulates the expression of developmental genes in the adult retina following optic nerve crush injury.Histology and histopathology · 2025Article
- The HH-GLI2-CKS1B network regulates the proliferation-to-maturation transition of cardiomyocytes.Stem cells translational medicine · 2024Article
- Turning gray selenium into a nanoaccelerator of tissue regeneration by PEG modification.Bioactive materials · 2022Article
- Importance of clitellar tissue in the regeneration ability of earthworm Eudrilus eugeniae.Functional & integrative genomics · 2022Article
- Self-Control of Inflammation during Tail Regeneration of Lizards.Journal of developmental biology · 2021Review
- Article
- Regenerative engineering: a review of recent advances and future directions.Regenerative medicine · 2021Review
- Hedgehog signaling regulates regenerative patterning and growth in Harmonia axyridis leg.Cellular and molecular life sciences : CMLS · 2021Article
- Harnessing hypoxia as an evolutionary driver of complex multicellularity.Interface focus · 2020Article
- Hedgehog Signal Inhibitor GANT61 Inhibits the Malignant Behavior of Undifferentiated Hepatocellular Carcinoma Cells by Targeting Non-Canonical GLI Signaling.International journal of molecular sciences · 2020Article
- Electrical stimulation shifts healing/scarring towards regeneration in a rat limb amputation model.Scientific reports · 2019Article
- Hedgehog and Wnt Signaling Pathways Regulate Tail Regeneration.Stem cells and development · 2018Article
- A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human.Nature communications · 2018Article
- TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms.Cellular and molecular life sciences : CMLS · 2018Article
- Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis.Nature communications · 2017Article
- Article
- The Quest toward limb regeneration: a regenerative engineering approach.Regenerative biomaterials · 2016Review
- Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage.Development (Cambridge, England) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Regulatory networks that govern embryonic development have been well defined. While a common hypothesis supports the notion that the embryonic regulatory cascades are reexpressed following injury and tissue regeneration, the mechanistic regulatory pathways that mediate the regenerative response in higher organisms remain undefined. Relative to mammals, lower vertebrates, including zebrafish and newts, have a tremendous regenerative capacity to repair and regenerate a number of organs including: appendages, retina, heart, jaw and nervous system. Elucidation of the pathways that govern regeneration in these lower organisms may provide cues that will enhance the capacity for the regeneration of mammalian organs. Signaling pathways, such as the hedgehog pathway, have been shown to play critical functions during development and during regeneration in lower organisms. These signaling pathways have been shown to modulate multiple processes including cellular origin, positional identity and cellular maturation. The present review will focus on the cellular and molecular regulation of the hedgehog (HH) signaling pathway and its interaction with other signaling factors during appendage development and regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.