Evidence map›Paper›PMID 26110172›Full record

ArticleThe archives of bone and joint surgery2015

Two-Stage Nerve Graft in Severe Scar: A Time-Course Study in a Rat Model.

Shayan Abdollah Zadegan, Masoumeh Firouzi, Mohammad Hossein Nabian, Leila Oriady Zanjani, Ahmad Mohebbi Ashtiani, Reza Shahryar Kamrani

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The archives of bone and joint surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Vascularization Strategies for Peripheral Nerve Tissue Engineering.Anatomical record (Hoboken, N.J. : 2007) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shayan Abdollah ZadeganShayan Abdollah Zadegan MD Masoumeh Firouzi PhD Tissue Repair Lab, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran Iran Research Center for Neural Repair (RCNR), University of Tehran, Tehran, Iran.
Masoumeh FirouziShayan Abdollah Zadegan MD Masoumeh Firouzi PhD Tissue Repair Lab, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran Iran Research Center for Neural Repair (RCNR), University of Tehran, Tehran, Iran.
Mohammad Hossein NabianShayan Abdollah Zadegan MD Masoumeh Firouzi PhD Tissue Repair Lab, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran Iran Research Center for Neural Repair (RCNR), University of Tehran, Tehran, Iran.
Leila Oriady ZanjaniShayan Abdollah Zadegan MD Masoumeh Firouzi PhD Tissue Repair Lab, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran Iran Research Center for Neural Repair (RCNR), University of Tehran, Tehran, Iran.
Ahmad Mohebbi AshtianiShayan Abdollah Zadegan MD Masoumeh Firouzi PhD Tissue Repair Lab, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran Iran Research Center for Neural Repair (RCNR), University of Tehran, Tehran, Iran.
Reza Shahryar KamraniShayan Abdollah Zadegan MD Masoumeh Firouzi PhD Tissue Repair Lab, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran Iran Research Center for Neural Repair (RCNR), University of Tehran, Tehran, Iran.
Institute of Biochemistry · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeripheral nerve repair outcomes are suboptimal in the presence of severe soft tissue injury and excessive scarring paralleling the process in tendon reconstruction of the hand. Inspired by the advantages of the two-stage technique in tendon grafting and with encouraging preliminary results, we aimed to investigate the two-stage nerve grafting technique as an alternative method of secondary nerve repair.

methodsThirty female rats (~200 g) were randomly distributed into two groups (n=15). A 15 mm gap was created in the sciatic nerve of the animals and an excessive extraneural scar was induced using the "mincing" method. In this method, a thin strip of muscle was removed, minced in a petri dish and returned to the peripheral nerve. In the two-stage nerve graft group, a silicone tube was interposed in the first stage. After 4 weeks, in the second stage, the silicone tube was removed and a median nerve autograft was interposed through the newly formed vascularized sheath. In the conventional graft group, two nerve ends were protected with silicone caps in the first stage. After 4 weeks the caps were removed and the median graft was interposed. Behavioral assessments were performed at week 15 after surgery with the withdrawal reflex latency (WRL) and extensor postural thrust (EPT) and at the 3, 6 and 15-week time points with the TOA (toe out angle). Masson Trichrome staining method was used for histological assessments at week 15.

resultsAccording to the EPT and WRL, the two-stage nerve graft showed significant improvement (P=0.020 and P=0.017 respectively). The TOA showed no significant difference between the two groups. The total vascular index was significantly higher in the two-stage nerve graft group (P<0.001).

conclusionsTwo-stage nerve graft using a silicone tube enhances vascularity of the graft and improves functional recovery.

Indexed as

GraftPeripheral nerve injuriesRatsScarSciatic nerve

Identifiers

PMID26110172
PMCPMC4468622
OpenAlexW1904192896

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.