Evidence map›Paper›PMID 26110169›Full record

ArticleOpen forum infectious diseases2015

Prevalence, Incidence, and Clearance of Anogenital Warts in Kenyan Men Reporting High-Risk Sexual Behavior, Including Men Who Have Sex With Men.

Santiago Neme, Elizabeth Wahome, Grace Mwashigadi, Alexander N Thiong'o, Joanne D Stekler, Anna Wald, Eduard J Sanders, Susan M Graham

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Santiago NemeDepartment of Medicine.
Elizabeth WahomeCentre for Geographic Medicine Research - Coast , Kenya Medical Research Institute , Kilifi.
Grace MwashigadiCentre for Geographic Medicine Research - Coast , Kenya Medical Research Institute , Kilifi.
Alexander N Thiong'oCentre for Geographic Medicine Research - Coast , Kenya Medical Research Institute , Kilifi.
Joanne D SteklerDepartment of Medicine.
Anna WaldDepartments of Epidemiology, Laboratory Medicine, and Medicine ; Vaccine and Infectious Disease Division , Fred Hutchinson Cancer Research Center , Seattle, Washington.
Eduard J SandersCentre for Geographic Medicine Research - Coast , Kenya Medical Research Institute , Kilifi ; Nuffield Department of Clinical Medicine , University of Oxford , Headington , United Kingdom.
Susan M GrahamDepartments of Medicine, Epidemiology, and Global Health , University of Washington , Seattle ; Centre for Geographic Medicine Research - Coast , Kenya Medical Research Institute , Kilifi.
Kenya Medical Research Institute · KEFred Hutch Cancer Center · USUniversity of Washington · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
Clinical Research in HSV InfectionsK24AI071113 · NIAID · UNIVERSITY OF WASHINGTON · PI WALD, ANNA · 2006 to 2015
$1.7M
Provider and Peer Support Intervention to Improve ART Adherence among Kenyan MenR34MH099946 · NIMH · UNIVERSITY OF WASHINGTON · PI GRAHAM, SUSAN MARIE · 2013 to 2015
$627k
NIAID NIH HHS K24 AI071113NIAID NIH HHS P30 AI027757NIAID NIH HHS T32 AI007140NIMH NIH HHS R34 MH099946Wellcome Trust 092654
6 · The paper itself

Abstract

Background.  Human papillomavirus (HPV) causes a spectrum of disease, ranging from warts to cancer. Prevalence, incidence, and factors associated with anogenital warts in East African men are unknown. Methods.  Kenyan men reporting high-risk sexual behavior were inspected for anogenital warts at enrollment and follow-up visits. Logistic regression was performed to identify associations with anogenital warts at baseline. Cox regression was performed to analyze predictors of incident anogenital warts, and Kaplan-Meier curves were used to estimate clearance. Results.  Baseline anogenital wart prevalence in 1137 men was 2.9% (95% confidence interval [CI], 2.0%-4.0%) overall, 2.0% in human immunodeficiency virus (HIV)-uninfected men, and 9.4% in HIV-1-infected men (adjusted odds ratio, 5.43; 95% CI, 2.03-11.29). Over a median of 1.4 years, anogenital wart incidence among 1104 men was 5.3 (95% CI, 4.3-6.5) per 100 person-years. Having HIV-1 infection at baseline (adjusted hazard ratio [aHR], 1.66; 95% CI, 1.01-2.72) or a genital syndrome during follow-up (aHR, 4.78; 95% CI, 3.03-7.56) was associated with increased wart incidence. Wart clearance was lower in HIV-1-infected men (log-rank P<.001). Conclusions.  Anogenital wart prevalence and incidence were increased in HIV-1-infected men, and anogenital warts co-occurred with other genital syndromes. Quadrivalent HPV vaccination should be recommended for young men in settings with high HIV-1 prevalence.

Indexed as

condylomata acuminatagenital wartsHIV-1HPVincidenceKenyamenMSM

Identifiers

PMID26110169
PMCPMC4473109
OpenAlexW2168730062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.