ArticleOpen forum infectious diseases2015
Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.
Susanna Naggie, Keyur Patel, Lan-Yan Yang, Shein-Chung Chow, Victoria Johnson, John R Guyton, Andrew J Muir, Mark Sulkowski, Charles Hicks
Open access · goldAbstract read
In one paragraphArticle in Open forum infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors at 7 institutions in 2 countries.
Susanna NaggieDuke Clinical Research Institute ; Duke University Medical Center.
Keyur PatelDuke Clinical Research Institute ; Duke University Medical Center.
Lan-Yan YangDuke Department of Biostatistics and Bioinformatics, Durham, North Carolina ; Clinical Trial Center , Chang Gung Memorial Hospital , Taoyuan , Taiwan.
Shein-Chung ChowDuke Department of Biostatistics and Bioinformatics, Durham, North Carolina.
Victoria JohnsonBirmingham VA Medical Center and University of Alabama.
John R GuytonDuke University Medical Center.
Andrew J MuirDuke Clinical Research Institute ; Duke University Medical Center.
Mark SulkowskiJohns Hopkins University , Baltimore, Maryland.
Charles HicksUniversity of California San Diego.
Clinical Research Institute · USBirmingham VA Medical Center · USChang Gung Memorial Hospital · TWDuke Medical Center · USDuke University · USJohns Hopkins University · USUniversity of California, San Diego · US
Funding
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1MStatistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6MValidation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8MSocial and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Susanna Naggie, GEORGIA Doris TOMARAS · 2005 to 2026
$50.5MPatient Oriented Research in Hepatitis C-infected Injection Drug UsersK24DA034621 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SULKOWSKI, MARK SEBASTIAN · 2012 to 2022
$1.2MMoving Towards More Individualized Therapies in HIV/HCV Co-infected PatientsK23AI096913 · NIAID · DUKE UNIVERSITY · PI NAGGIE, SUSANNA · 2011 to 2014
$355kNIAID NIH HHS K23 AI096913NIAID NIH HHS P30 AI064518NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI106701NIDA NIH HHS K24 DA034621
6 · The paper itselfAbstract
We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log10 HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients.
Indexed as
apolipoprotein CIIIapolipoproteinsHCVHCV RNAHIVlipoproteins
Identifiers
PMID26110167
PMCPMC4473112
OpenAlexW1939323311
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