ArticleOpen forum infectious diseases2015
Metabolic Signature Profiling as a Diagnostic and Prognostic Tool in Pediatric Plasmodium falciparum Malaria.
Article in Open forum infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling.Redox biology · 2018Trial
- Longitudinal plasma metabolomics reveals a role for taurine in asymptomatic malaria and seasonal persistence.Nature microbiology · 2026Article
- Temporal multi-tissue profiling reveals metabolites linked to immune response and malaria parasitemia control.iScience · 2026Article
- Article
- Metabolomics in infectious diseases and drug discovery.Molecular omics · 2021Review
- Insights into malaria pathogenesis gained from host metabolomics.PLoS pathogens · 2020Article
- Mining the Human Host Metabolome Toward an Improved Understanding of Malaria Transmission.Frontiers in microbiology · 2020Review
- From Metabolite to Metabolome: Metabolomics Applications inFrontiers in microbiology · 2020Review
- Distinct amino acid and lipid perturbations characterize acute versus chronic malaria.JCI insight · 2019Article
- Insights into physiological roles of unique metabolites released from Plasmodium-infected RBCs and their potential as clinical biomarkers for malaria.Scientific reports · 2019Article
- Biologically ActiveFrontiers in pharmacology · 2019Article
- Levels of human proteins in plasma associated with acute paediatric malaria.Malaria journal · 2018Article
- Systems Biology-Based Investigation of Host-Plasmodium Interactions.Trends in parasitology · 2018Review
- Metabolome-wide association study of peripheral parasitemia in Plasmodium vivax malaria.International journal of medical microbiology : IJMM · 2017Article
- The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children.Malaria journal · 2017Article
- A metabolomic analytical approach permits identification of urinary biomarkers for Plasmodium falciparum infection: a case-control study.Malaria journal · 2017Article
- Lipid response patterns in acute phase paediatricMetabolomics : Official journal of the Metabolomic Society · 2017Article
- Towards Improving Point-of-Care Diagnosis of Non-malaria Febrile Illness: A Metabolomics Approach.PLoS neglected tropical diseases · 2016Article
- Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression.Experientia supplementum (2012)Review
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background. Accuracy in malaria diagnosis and staging is vital to reduce mortality and post infectious sequelae. In this study, we present a metabolomics approach to diagnostic staging of malaria infection, specifically Plasmodium falciparum infection in children. Methods. A group of 421 patients between 6 months and 6 years of age with mild and severe states of malaria with age-matched controls were included in the study, 107, 192, and 122, individuals, respectively. A multivariate design was used as basis for representative selection of 20 patients in each category. Patient plasma was subjected to gas chromatography-mass spectrometry analysis, and a full metabolite profile was produced from each patient. In addition, a proof-of-concept model was tested in a Plasmodium berghei in vivo model where metabolic profiles were discernible over time of infection. Results. A 2-component principal component analysis revealed that the patients could be separated into disease categories according to metabolite profiles, independently of any clinical information. Furthermore, 2 subgroups could be identified in the mild malaria cohort who we believe represent patients with divergent prognoses. Conclusions. Metabolite signature profiling could be used both for decision support in disease staging and prognostication.
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