Evidence map›Paper›PMID 26110145›Full record

ArticleIranian journal of public health2014

Gene-Gene Interactions among Pparα/δ/γ Polymorphisms for Apolipoprotein (Apo) A-I/Apob Ratio in Chinese Han Population.

Bo Hai, Huijian Xie, Zhirong Guo, Chen Dong, Ming Wu, Qiu Chen, Zhengyuan Zhou, Qiurong Zhu, Mengmeng Liu, Wei Fan and 1 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Bo Hai1. Dept. of Epidemiology, School of Public Health, Soochow University , Suzhou, JiangSu, China.
Huijian Xie1. Dept. of Epidemiology, School of Public Health, Soochow University , Suzhou, JiangSu, China.
Zhirong Guo1. Dept. of Epidemiology, School of Public Health, Soochow University , Suzhou, JiangSu, China.
Chen Dong1. Dept. of Epidemiology, School of Public Health, Soochow University , Suzhou, JiangSu, China.
Ming Wu2. Center for Disease Control and Prevention of Nanjing , Jiangsu, China.
Qiu Chen1. Dept. of Epidemiology, School of Public Health, Soochow University , Suzhou, JiangSu, China.
Zhengyuan Zhou3. Center for Disease Control of Changshu City , Suzhou, JiangSu, China.
Qiurong Zhu1. Dept. of Epidemiology, School of Public Health, Soochow University , Suzhou, JiangSu, China.
Mengmeng Liu1. Dept. of Epidemiology, School of Public Health, Soochow University , Suzhou, JiangSu, China.
Wei Fan1. Dept. of Epidemiology, School of Public Health, Soochow University , Suzhou, JiangSu, China.
Hui Zhou1. Dept. of Epidemiology, School of Public Health, Soochow University , Suzhou, JiangSu, China.
Soochow University · CNJiangsu Provincial Center for Disease Control and Prevention · CNSuzhou University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe peroxisome proliferator-activated receptors (PPARs) -α, -δ/β and -γ are the ligand-activated transcription factors involved in the regulation of fatty acid and lipoprotein metabolism, energy balance, cell proliferation and differentiation and atherosclerosis, etc. We investigated the associations of 10 single-nucleotide polymorphisms (SNPs) in PPARs with apolipoprotein (apo) A-I/apoB ratio in Chinese Han population.

methodsOverall, 630 subjects (212 males, 418 females) were randomly selected from the Prevention of Metabolic Syndrome and Multiple Metabolic Disorders in Jiangsu Province of China Study Cohort. Population analyzed was as the general population which involved healthy people and individuals with disorders of apoA-I or apoB. 10 SNPs (rs1800206, rs135539, rs4253778, rs2016520, rs9794, rs10865710, rs1805192, rs709158, rs3856806 and rs4684847) were genotyped. Mean difference (Difference) and 95% confident interval (95%CI) were calculated.

resultsAfter covariates adjustment, rs1800206-V allele (LV+VV) and rs3856806-T allele (CT+TT) were significantly associated with a decreased apoA-I/apoB ratio than those wild type carriers, Difference (95%CI) were -1.29 (-1.96-0.62) and -0.8 (-1.42~-0.17), respectively. Rs4253778-C allele was significantly associated with an increased apoA-I/apoB ratio compared to the wild type carriers (GG), Difference (95%CI) was 0.76 (0.04-1.48). Generalized multifactor dimensionality reduction analysis showed that three-to-eight-locus models were significant with apoA-I/apoB ratio (P<0.05). We chose the seven-locus model (P=0.0010) as the best GMDR model (cross-validation consistency was 7/10 and testing accuracy was 62.97%).

conclusionOur data provided the evidence that PPARs polymorphisms might be involved in regulation of apoA-I/apoB ratio in independently and/or in an interactive manner.

Indexed as

Apolipoprotein (apo) A-I/apoB ratioInteractionPeroxisome proliferator-activated receptorsPolymorphism

Identifiers

PMID26110145
PMCPMC4475593
OpenAlexW2123829210

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.