Evidence map›Paper›PMID 26110140›Full record

ReviewIranian journal of public health2014

Metallothionein Lower Under-Expression in Benign Tumors than That in Malignant Tumors: Systematic Review Article and Meta-Analysis.

Jie Zhang, Ruijie Sun, Yue Liu, Guinian Wang, Qinglu Wang

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Iranian journal of public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jie Zhang1. Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Shandong Wanjie Medical College , Zibo, China.
Ruijie Sun2. Dept. of Medicine, Shandong Wanjie Medical College , Zibo, China.
Yue Liu1. Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Shandong Wanjie Medical College , Zibo, China.
Guinian Wang3. Dept. of Laboratory Medicine, the First Hospital of Zibo City , Zibo, China.
Qinglu Wang1. Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Shandong Wanjie Medical College , Zibo, China.
Shandong University of Technology · CNCentral Hospital of Zibo · CNZibo Vocational Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metallothionein (MT) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. A meta-analysis was conducted to evaluate comprehensively the MT expression difference in various benign tumors and malignant tumors, which compared the high with low MT expression levels in patients of the available studies. Finally, a total of 13 studies dealing with various tumors were involved for this meta-analysis. The results indicated that lower expression of MT in various benign tumors tissue than that in corresponding malignant tumors with the pooled OR of 0.52 (95 % CI 0.18-1.47, P < 0.001). In conclusion, MT expression difference is associated with tumor various stages in tumor patients and could be a useful clinical criteria of distinguishing benign tumors and malignant tumors for those patients.

Indexed as

Benign tumorsMalignant tumorsMeta-analysisMetallothionein

Identifiers

PMID26110140
PMCPMC4475588
OpenAlexW2144198780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.