Evidence map›Paper›PMID 26110130›Full record

ArticleNorth American journal of medical sciences2015

Status of Superoxide Dismutase in Transfusion Dependent Thalassaemia.

Lantip Rujito, Sri Mulatsih, Abdul Salam M Sofro

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in North American journal of medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 14 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Lantip RujitoDepartment of Molecular Biology, Medical Faculty of Jenderal Soedirman University, Purwokerto, Indonesia.
Sri MulatsihDepartment of Pediatric, Sardjito National Hospital, Yogyakarta, Indonesia.
Abdul Salam M SofroDepartment of Biochemistry, Medical Faculty of Yayasan Rumah Sakit Islam Indonesia University, Jakarta, Indonesia.
Islamic University of Indonesia · IDJenderal Soedirman University · IDRumah Sakit Umum Pusat Dr. Sardjito · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThalassemia is a collection of genetic impairments in beta and alpha genes causing various states of anemia. Severe types of the disease need lifelong transfusions, leading to oxidant-antioxidant disturbance due to massive iron deposits.

aimsThe aim of this study was to assess the antioxidant enzyme Superoxide Dismutase (SOD) and ferritin levels of thalassemia major patients in a peripheral health facility. MATERIALS AND

methodsTwo hundred and nine probands were recruited and performed laboratory experiments for SOD and Ferritin levels. Chelation administration and clinical score were taken from interviewing the family and from medical report data.

resultsThe study showed that SOD intensity was lower (162.41 u/ml) compared to the normal cutoff point (P = 0.001), while the mean of Ferritin levels was ten times over the normal value (4226,67 ng/dl). Observations also reported that chelation medicine was not administrated properly.

conclusionsThe data indicates that thalassemic patients have oxidant-antioxidant uproar due to oxidative stress. Monitored chelating administration, selective antioxidant, and a well-balanced diet may prevent oxidative injury.

Indexed as

Oxidant-antioxidantsuperoxide dismutasethalassaemia

Identifiers

PMID26110130
PMCPMC4462814
OpenAlexW1503330376

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.