ArticleInternational journal for parasitology. Parasites and wildlife2015
Wild chimpanzees are infected by Trypanosoma brucei.
Article in International journal for parasitology. Parasites and wildlife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2020Pooled it
- Wildlife surveys detectCurrent research in parasitology & vector-borne diseases · 2026Article
- Development and Assessment of a Multiple-Analysis System for Diagnosing Malaria and Other Blood Parasite Infections in Humans and Non-Human Primates.Diagnostics (Basel, Switzerland) · 2025Article
- Consistent detection of Trypanosoma brucei but not T. congolense DNA in faeces of experimentally infected cattle.Scientific reports · 2024Article
- First Molecular Identification of Trypanosomes and Absence ofPathogens (Basel, Switzerland) · 2022Article
- Molecular Detection and Characterization of Intestinal and Blood Parasites in Wild Chimpanzees (Animals : an open access journal from MDPI · 2021Article
- Zoonotic Blood-Borne Pathogens in Non-Human Primates in the Neotropical Region: A Systematic Review.Pathogens (Basel, Switzerland) · 2021Review
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- A review of research in primate sanctuaries.Biology letters · 2020Review
- An unexpected diversity of trypanosomatids in fecal samples of great apes.International journal for parasitology. Parasites and wildlife · 2018Article
- Article
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Authors and funding
14 authors at 9 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although wild chimpanzees and other African great apes live in regions endemic for African sleeping sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples. In present work, we established a diagnostic ITS1-based PCR assay that allows detection of the DNA of all four Trypanosoma brucei subspecies (Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, Trypanosoma brucei gambiense, and Trypanosoma brucei evansi) in feces of experimentally infected mice. Next, using this assay we revealed the presence of trypanosomes in the fecal samples of wild chimpanzees and this finding was further supported by results obtained using a set of primate tissue samples. Phylogenetic analysis of the ITS1 region showed that the majority of obtained sequences fell into the robust T. brucei group, providing strong evidence that these infections were caused by T. b. rhodesiense and/or T. b. gambiense. The optimized technique of trypanosome detection in feces will improve our knowledge about the epidemiology of trypanosomes in primates and possibly also other endangered mammals, from which blood and tissue samples cannot be obtained. Finally, we demonstrated that the mandrill serum was able to efficiently lyse T. b. brucei and T. b. rhodesiense, and to some extent T. b. gambiense, while the chimpanzee serum failed to lyse any of these subspecies.
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