Evidence map›Paper›PMID 26110064›Full record

ArticleScientific data2015

Proteomic analysis of colon and rectal carcinoma using standard and customized databases.

Robbert J C Slebos, Xia Wang, Xiaojing Wang, Xaojing Wang, Bing Zhang, David L Tabb, Daniel C Liebler

Erratum issuedAbstract readDataset
In one paragraph

Article in Scientific data, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  11. Tag-Count Analysis of Large-Scale Proteomic Data.Journal of proteome research · 2016
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Robbert J C SlebosDepartment of Biochemistry, Vanderbilt University School of Medicine , Nashville, TN 37232, USA ; Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt-Ingram Cancer Center , Nashville, TN 37232, USA.
Xia WangDepartment of Mathematical Sciences, University of Cincinnati , Cincinnati, OH 45221, USA.
Xiaojing WangDepartment of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, TN 37232, USA.
Xaojing WangDepartment of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, TN 37232, USA.
Bing ZhangDepartment of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, TN 37232, USA.
David L TabbDepartment of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, TN 37232, USA.
Daniel C LieblerDepartment of Biochemistry, Vanderbilt University School of Medicine , Nashville, TN 37232, USA ; Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt-Ingram Cancer Center , Nashville, TN 37232, USA.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Understanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6M
Vanderbilt Proteome Characterization CenterU24CA159988 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LIEBLER, DANIEL C · 2011 to 2016
$13.9M
Systems Approach to the Biological Basis of Colon Cancer MetastasesR01GM088822 · NIGMS · VANDERBILT UNIVERSITY · PI BEAUCHAMP, ROBERT DANIEL, ZHANG, BING · 2009 to 2012
$1.5M
NCI NIH HHS P30 CA068485NCI NIH HHS P30CA068485NCI NIH HHS P50 CA095103NCI NIH HHS P50CA095103NCI NIH HHS U24 CA159988NCI NIH HHS U24CA159988NIGMS NIH HHS GM088822NIGMS NIH HHS R01 GM088822
6 · The paper itself

Abstract

Understanding proteomic differences underlying the different phenotypic classes of colon and rectal carcinoma is important and may eventually lead to a better assessment of clinical behavior of these cancers. We here present a comprehensive description of the proteomic data obtained from 90 colon and rectal carcinomas previously subjected to genomic analysis by The Cancer Genome Atlas (TCGA). Here, the primary instrument files and derived secondary data files are compiled and presented in forms that will allow further analyses of the biology of colon and rectal carcinoma. We also discuss new challenges in processing these large proteomic datasets for relevant proteins and protein variants.

Indexed as

Colonic NeoplasmsProteomicsRectal NeoplasmsDatabases, ProteinElectronic Data ProcessingHumans

Identifiers

PMID26110064
PMCPMC4477697

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.