Evidence map›Paper›PMID 26109989›Full record

ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2015

The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population.

Ayman A El-Menyar, Nasser M Rizk, Awad Al-Qahtani, Fahad AlKindi, Ahmed Elyas, Fathi Farag, Fadheela Dad Bakhsh, Samah Ebrahim, Emad Ahmed, Mooza Al-Khinji and 2 more

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In one paragraph

Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ayman A El-MenyarDepartment of Clinical medicine, Weill Cornell Medical School, Doha, Qatar ; Department of Surgery, Clinical Research, Hamad General Hospital, Doha, Qatar ; Department of Internal Medicine, Ahmed Maher Teaching Hospital, Cairo, Egypt.
Nasser M RizkDepartment of Health Sciences, CAS, Qatar University, Doha, Qatar ; Department of Physiology, Faculty of Medicine, Al-Mansoura, Egypt.
Awad Al-QahtaniDepartment of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
Fahad AlKindiDepartment of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
Ahmed ElyasDepartment of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
Fathi FaragDepartment of Internal Medicine, Al Emadi Hospital, Doha, Qatar.
Fadheela Dad BakhshDepartment of Health Sciences, CAS, Qatar University, Doha, Qatar.
Samah EbrahimDepartment of Health Sciences, CAS, Qatar University, Doha, Qatar.
Emad AhmedDepartment of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
Mooza Al-KhinjiDepartment of Clinical Chemistry, Hamad Medical Corporation, Doha, Qatar.
Hassan Al-ThaniDepartment of Surgery, Vascular Surgery, Hamad General Hospital, Doha, Qatar.
Jassim Al SuwaidiDepartment of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
Hamad Medical Corporation · QAQatar University · QAHamad General Hospital · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBased on several reports including genome-wide association studies, genetic variability has been linked with higher (nearly half) susceptibility toward coronary artery disease (CAD). We aimed to evaluate the association of chromosome 9p21 single nucleotide polymorphisms (SNPs): rs2383207, rs10757278, and rs10757274 with the risk and severity of CAD among Arab population. MATERIALS AND

methodsA prospective observational case-control study was conducted between 2011 and 2012, in which 236 patients with CAD were recruited from the Heart Hospital in Qatar. Patients were categorized according to their coronary angiographic findings. Also, 152 healthy volunteers were studied to determine if SNPs are associated with risk of CAD. All subjects were genotyped for SNPs (rs2383207, rs2383206, rs10757274 and rs10757278) using allele-specific real-time polymerase chain reaction.

resultsPatients with CAD had a mean age of 57 ± 10; of them 77% were males, 54% diabetics, and 25% had family history of CAD. All SNPs were in Hardy-Weinberg equilibrium except rs2383206, with call rate >97%. After adjusting for age, sex and body mass index, the carriers of GG genotype for rs2383207 have increased the risk of having CAD with odds ratio (OR) of 1.52 (95% confidence interval [CI] = 1.01-2.961, P = 0.046). Also, rs2383207 contributed to CAD severity with adjusted OR 1.80 (95% CI = 1.04-3.12, P = 0.035) based on the dominant genetic model. The other SNPs (rs10757274 and rs10757278) showed no significant association with the risk of CAD or its severity.

conclusionAmong Arab population in Qatar, only G allele of rs2483207 SNP is significantly associated with risk of CAD and its severity.

Indexed as

Chromosome 9p21coronary artery diseaseQatarsingle nucleotide polymorphisms

Identifiers

PMID26109989
PMCPMC4468449
OpenAlexW888257109

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LicenceCC BY-NC-SA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.