Evidence map›Paper›PMID 26109954›Full record

ArticleNeural regeneration research2015

MicroRNA-124 slows down the progression of Huntington's disease by promoting neurogenesis in the striatum.

Tian Liu, Wooseok Im, Inhee Mook-Jung, Manho Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies-advances and challenges.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tian LiuDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.
Wooseok ImDepartment of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.
Inhee Mook-JungDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea ; Department of Biochemistry, Seoul National University College of Medicine, Seoul, South Korea.
Manho KimDepartment of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea ; Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul, South Korea.
Seoul National University · KRSeoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNA-124 contributes to neurogenesis through regulating its targets, but its expression both in the brain of Huntington's disease mouse models and patients is decreased. However, the effects of microRNA-124 on the progression of Huntington's disease have not been reported. Results from this study showed that microRNA-124 increased the latency to fall for each R6/2 Huntington's disease transgenic mouse in the rotarod test. 5-Bromo-2'-deoxyuridine (BrdU) staining of the striatum shows an increase in neurogenesis. In addition, brain-derived neurotrophic factor and peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein levels in the striatum were increased and SRY-related HMG box transcription factor 9 protein level was decreased. These findings suggest that microRNA-124 slows down the progression of Huntington's disease possibly through its important role in neuronal differentiation and survival.

Indexed as

brain-derived neurotrophic factor; peroxisomeHuntington's diseasemicroRNA-124mutant huntingtinnerve regenerationneurogenesisneuronal survivalproliferator-activated receptor gamma coactivator 1-alphaSRY-related HMG box transcription factor 9

Identifiers

PMID26109954
PMCPMC4468771
OpenAlexW1537130989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.