ArticleReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
Volumetric modulated arc therapy in prostate cancer patients with metallic hip prostheses in a UK centre.
Article in Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Development of nasopharyngeal carcinoma target delineation: from two-dimensional radiotherapy to adaptive precision radiotherapy.Journal of Cancer · 2026Review
- The impact of metal implants on the dose and clinical outcome of radiotherapy (Review).Molecular and clinical oncology · 2024Review
- Stereotactic Body Radiation Therapy (SBRT) in prostate cancer in the presence of hip prosthesis - is it a contraindication? A narrative review.BMC urology · 2024Review
- Article
- Radiotherapy-induced toxicity in prostate cancer patients with hip prostheses.Radiation oncology (London, England) · 2022Article
- The feasibility of a dose painting procedure to treat prostate cancer based on mpMR images and hierarchical clustering.Radiation oncology (London, England) · 2021Article
- [Radiotherapy after tumour prostheses-status, indication, coordination].Der Orthopade · 2019Review
- Volumetric modulated arc therapy for treatment of solid tumors: current insights.OncoTargets and therapy · 2017Review
- Evaluation of VMAT Planning Strategies for Prostate Patients with Bilateral Hip Prosthesis.Technology in cancer research & treatmentArticle
- VMAT Optimization and Dose Calculation in the Presence of Metallic Hip Prostheses.Technology in cancer research & treatmentArticle
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to investigate whether IMRT using VMAT is a viable and safe solution in dose escalated RT in these patients.
backgroundAn increasing number of prostate cancer patients are elderly and have hip prostheses. These implants pose challenges in radiotherapy treatment planning. Although intensity modulated radiotherapy (IMRT) is commonly used, there is a lack of clinical studies documenting its efficacy and toxicities in this subgroup of patients. MATERIALS AND
methodsThe data from 23 patients with hip prostheses and non-metastatic prostate cancer treated with VMAT (volumetric modulated arc therapy) between 2009 and 2011, were retrospectively analyzed. Baseline characteristics, treatment details and outcome data were collected on all patients. The median follow up was 40.9 months. MRI-CT image fusion was performed and the treatment plans were created using RapidArc™ (RA) techniques utilizing 1 or 2 arcs and 10 MV photon beams.
results96% of patients were treated with a dose of 72 Gy/32 fractions over 44 days. 21/23 plans met the PTV targets. The mean homogeneity index was 1.07. 20/23 plans met all OAR constraints (rectum, bladder). Two plans deviated from rectal constraints, four from bladder constraints; all were classed as minor deviations. One patient experienced late grade 3 genitourinary toxicity. Three other patients experienced late grade 2 or lower gastrointestinal toxicity. One patient had biochemical failure and one had a non-prostate cancer related death.
conclusionsVMAT provides an elegant solution to deliver dose escalated RT in patients with unilateral and bilateral hip replacements with minimal acute and late toxicities.
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