Evidence map›Paper›PMID 26109864›Full record

ReviewTherapeutics and clinical risk management2015

Optimal management of digital ulcers in systemic sclerosis.

Shawn Abraham, Virginia Steen

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Therapeutics and clinical risk management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02801305 phase2completednot on this mapstarted 2016, after this paper: background citation

Assessing and Comparing the Effect of Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers.

TypeinterventionalSponsorMohammad Ali NazariniaRan2016 to 2017Enrolled90ConditionsDigital Ulcer of SclerodermaArmsDiltiazem Gel 2%, Nitroglycerin Ointment 2%, Vaseline
NCT05204784 naunknown statusnot on this mapstarted 2022, after this paper: background citation

A Randomized Controlled Prospective Single-center Feasibility Study of Rheopheresis for Raynaud's Syndrome and Digital Ulcers in Systemic Sclerosis

TypeinterventionalSponsorPeter KorstenRan2022 to 2024Enrolled30ConditionsSystemic Sclerosis, Raynaud Phenomenon, Digital Ulcer, SclerodermaArmsRheopheresis treatment, Intravenous Infusion
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Microvascular Hand Surgery for Digital Ischemia in Scleroderma.Journal of scleroderma and related disorders · 2020
    Article
  8. Complementary therapies for patients with systemic sclerosis.Journal of scleroderma and related disorders · 2019
    Review
  9. Observational
  10. Article
  11. Article
  12. Review of local wound management for scleroderma-associated digital ulcers.Journal of scleroderma and related disorders · 2018
    Article
  13. Evidence-based management of Raynaud's phenomenon.Therapeutic advances in musculoskeletal disease · 2017
    Review
  14. The critical need for accurately defining digital ulcers in scleroderma.Journal of scleroderma and related disorders · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Shawn AbrahamDivision of Rheumatology, immunology, and Allergy, MedStar Georgetown University Hospital, Washington, DC, USA.
Virginia SteenDivision of Rheumatology, immunology, and Allergy, MedStar Georgetown University Hospital, Washington, DC, USA.
Georgetown University · USMedStar Georgetown University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Raynaud's phenomenon and digital ulcerations are two common clinical features seen in patients with systemic sclerosis. They are painful and lead to significant morbidity and altered hand function within this patient population. While currently there are no US Food and Drug Administration (FDA)-approved medications for the treatment of digital ulcerations in the United States, clinical trials have supported the use of pharmacologic and nonpharmacologic modalities in facilitating healing of existing digital ulcers and preventing formation of new ulcers. This article reviews the published data on these therapeutic options.

Indexed as

digital ulcersRaynaud’s phenomenonsclerodermasystemic sclerosistreatment

Identifiers

PMID26109864
PMCPMC4474386
OpenAlexW1707511973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.