ArticleDrug design, development and therapy2015
Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells.
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Article in Drug design, development and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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21 citing papers in PubMed, 39 citations in OpenAlex.
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- Potential Effects of Nutraceuticals in Retinopathy of Prematurity.Life (Basel, Switzerland) · 2021Review
- Ursolic and Oleanolic Acids Induce Mitophagy in A549 Human Lung Cancer Cells.Molecules (Basel, Switzerland) · 2019Article
- Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity.Planta medica · 2019Review
- Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives.Bioorganic & medicinal chemistry · 2018Article
- Oleanolic acid induces p53-dependent apoptosisOncotarget · 2018Article
- GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway.Scientific reports · 2018Article
- Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.International review of cell and molecular biology · 2018Review
- AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells.Oncotarget · 2017Article
- Chloride intracellular channel 1 regulates the antineoplastic effects of metformin in gallbladder cancer cells.Cancer science · 2017Article
- Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy.International journal of molecular sciences · 2017Review
- Synergistic Antitumour Properties ofJournal of immunology research · 2017Article
- Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling.International journal of clinical and experimental pathology · 2015Article
- HCV core protein represses the apoptosis and improves the autophagy of human hepatocytes.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
16 authors at 3 institutions in 3 countries.
Huai-Feng LiDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Xu-An WangDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Shan-Shan XiangDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Yun-Ping HuDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Lin JiangDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Yi-Jun ShuDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Mao-Lan LiDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Xiang-Song WuDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Fei ZhangDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Yuan-Yuan YeDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Hao WengDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Run-Fa BaoDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Yang CaoDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Wei LuDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Qian DongDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
Ying-Bin LiuDepartment of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Laboratory of General Surgery, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China ; Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People's Republic of China.
XinHua Hospital · CNShanghai Jiao Tong University · CNInstitute of Liver and Biliary Sciences · IN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oleanolic acid (OA), a naturally occurring triterpenoid, exhibits potential antitumor activity in many tumor cell lines. Gallbladder carcinoma is the most common malignancy of the biliary tract, and is a highly aggressive tumor with an extremely poor prognosis. Unfortunately, the effects of OA on gallbladder carcinoma are unknown. In this study, we investigated the effects of OA on gallbladder cancer cells and the underlying mechanism. The results showed that OA inhibits proliferation of gallbladder cancer cells in a dose-dependent and time-dependent manner on MTT and colony formation assay. A flow cytometry assay revealed apoptosis and G0/G1 phase arrest in GBC-SD and NOZ cells. Western blot analysis and a mitochondrial membrane potential assay demonstrated that OA functions through the mitochondrial apoptosis pathway. Moreover, this drug inhibited tumor growth in nude mice carrying subcutaneous NOZ tumor xenografts. These data suggest that OA inhibits proliferation of gallbladder cancer cells by regulating apoptosis and the cell cycle process. Thus, OA may be a promising drug for adjuvant chemotherapy in gallbladder carcinoma.
Indexed as
AnimalsAntineoplastic AgentsApoptosisCell Line, TumorDose-Response Relationship, DrugG1 PhaseGallbladder NeoplasmsHumansMaleMembrane Potential, MitochondrialMiceMice, NudeMitochondriaOleanolic AcidResting Phase, Cell CycleTetrazolium SaltsAntineoplastic AgentsOleanolic AcidTetrazolium SaltsThiazolesthiazolyl blueapoptosiscell cycle arrestgallbladder carcinomamitochondrial pathwayoleanolic acid
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