Observational studyWorld journal of gastroenterology2015
Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012.
Observational study in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018Pooled it
- Achievement of Endoscopic Remission After Induction Reduces Hospitalization Burden in Crohn's Disease: Findings From a Pooled Post Hoc Analysis of Risankizumab and Upadacitinib Phase III Trials.Journal of Crohn's & colitis · 2025Trial
- Development and Validation of a Clinical Decision Support Tool to Predict Disease Progression in Crohn's Disease Treated with Ustekinumab.Journal of clinical medicine · 2025Article
- Surgery time for stenosed Crohn's disease: Case report.International journal of surgery case reports · 2025Article
- Early Endoscopic Outcomes After Risankizumab Are Associated With Fewer Hospitalizations and Surgeries in Crohn's Disease.Gastro hep advances · 2025Article
- Effect of Risankizumab Induction and Maintenance Therapy on the Rate of Hospitalization in Patients with Crohn's Disease.Gastro hep advances · 2025Article
- Progression of Crohn's Disease in Newly Diagnosed Patients: Results from an Observational Study Using US Claims Data.Digestive diseases and sciences · 2024Observational
- Clinical and health care utilization variables can predict 90-day hospital re-admission in adults with Crohn's disease for point of care risk evaluation.BMC gastroenterology · 2024Article
- Creation of an Inflammatory Bowel Disease Referral Pathway for Identifying Patients Who Would Benefit From Inflammatory Bowel Disease Specialist Consultation.Inflammatory bowel diseases · 2023Review
- Evaluation of Treatment Patterns and Maintenance Dose Titration Among Patients With Crohn's Disease Initiating Biologics With 3 Years of Follow-Up.Journal of health economics and outcomes research · 2023Article
- Variables associated with progression of moderate-to-severe Crohn's disease.BMJ open gastroenterology · 2022Article
- Long-term clinical and real-world experience with Crohn's disease treated with anti-tumor necrosis factor-α antibodies.Intestinal research · 2022Article
- Cost-Effectiveness of Tight Control for Crohn's Disease With Adalimumab-Based Treatment: Economic Evaluation of the CALM Trial From a Canadian Perspective.Journal of the Canadian Association of Gastroenterology · 2022Article
- Adalimumab Is Associated With Lower Healthcare Resource and Steroid Use Versus Vedolizumab in Biologic-Naive Crohn's Disease: A Retrospective Claims Database Analysis.Crohn's & colitis 360 · 2022Article
- Crohn's disease: a population-based study of surgery in the age of biological therapy.International journal of colorectal disease · 2021Article
- Hospitalization and surgery rates in patients with inflammatory bowel disease in Brazil: a time-trend analysis.BMC gastroenterology · 2021Article
- Prevention and Treatment of Stricturing Crohn's Disease - Perspectives and Challenges.Expert review of gastroenterology & hepatology · 2021Review
- Time Trends of Crohn's Disease in Catalonia from 2011 to 2017. Increasing Use of Biologics Correlates with a Reduced Need for Surgery.Journal of clinical medicine · 2020Article
- Development of a prognostic model for one-year surgery risk in Crohn's disease patients: A retrospective study.World journal of gastroenterology · 2020Article
- Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn's Disease.Journal of the Canadian Association of Gastroenterology · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo analyze the prevalence, length and predictors of hospitalization in the biological era in the population-based inception cohort from Veszprem province.
methodsData of 331 incident Crohn's disease (CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed (median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.
resultsProbabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%, 53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures (37%), surgery or disease activity (27% and 21%). Non-inflammatory disease behavior at diagnosis (HR = 1.32, P = 0.001) and perianal disease (HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change (HR = 2.38, P = 0.002) and need for steroids (HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses. Early CD-related hospitalization (within the year of diagnosis) was independently associated with need for immunosuppressives (OR = 2.08, P = 0.001) and need for surgeries (OR = 7.25, P < 0.001) during the disease course.
conclusionHospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and re-hospitalization.
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