ArticleWorld journal of gastroenterology2015
PillCam COLON 2 in Crohn's disease: A new concept of pan-enteric mucosal healing assessment.
Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03616041 (Video Capsule Endoscopy for Lesion Localization and Diagnosis in Patients With Severe Hematochezia), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Video Capsule Endoscopy for Lesion Localization and Diagnosis in Patients With Severe Hematochezia
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Characterization of Mucosal Lesions in Crohn's Disease Scored With Capsule Endoscopy: A Systematic Review.Frontiers in medicine · 2020Pooled it
- A novel PillCam Crohn's capsule score (Eliakim score) for quantification of mucosal inflammation in Crohn's disease.United European gastroenterology journal · 2020Trial
- Artificial intelligence in the management of inflammatory bowel disease: What's next?World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- The Role of Video Capsule Endoscopy in Hereditary Polyposis Syndromes: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Best Approach for Incomplete Colonoscopy: Colon Capsule Endoscopy or Repeat Conventional Colonoscopy?GE Portuguese journal of gastroenterology · 2025Article
- Assessment of the effect of prokinetic drugs on transit time and gastrointestinal cleanliness in capsule endoscopy.BMC veterinary research · 2025Article
- The Diagnostic Accuracy of Colon Capsule Endoscopy in Inflammatory Bowel Disease-A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2024Review
- Pan-Enteric Capsule Endoscopy: Current Applications and Future Perspectives.GE Portuguese journal of gastroenterology · 2024Review
- Capsule endoscopy and panendoscopy: A journey to the future of gastrointestinal endoscopy.World journal of gastroenterology · 2024Article
- Robotic Pills as Innovative Personalized Medicine Tools: A Mini Review.Recent advances in drug delivery and formulation · 2024Review
- Capsule Endoscopy in Inflammatory Bowel Disease: Panenteric Capsule Endoscopy and Application of Artificial Intelligence.Gut and liver · 2023Article
- The Prediction of Inadequate Colon Capsule Cleansing: A Cohort Selection Guided by CC-CLEAR.GE Portuguese journal of gastroenterology · 2022Article
- Video capsule endoscopy in inflammatory bowel disease.DEN open · 2022Review
- Review: Colon Capsule Endoscopy in Inflammatory Bowel Disease.Diagnostics (Basel, Switzerland) · 2022Review
- Key research questions for implementation of artificial intelligence in capsule endoscopy.Therapeutic advances in gastroenterology · 2022Article
- Colon Capsule Endoscopy in the Assessment of Mucosal Healing in Crohn's Disease.Inflammatory bowel diseases · 2021Article
- Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis.Endoscopy international open · 2021Review
- Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study.Nagoya journal of medical science · 2021Article
- The Entire Intestinal Tract Surveillance Using Capsule Endoscopy after Immune Checkpoint Inhibitor Administration: A Prospective Observational Study.Diagnostics (Basel, Switzerland) · 2021Article
- Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract.BMC gastroenterology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate mucosal healing in patients with small bowel plus colonic Crohn's disease (CD) with a single non-invasive examination, by using PillCam COLON 2 (PCC2).
methodsPatients with non-stricturing nonpenetrating small bowel plus colonic CD in sustained corticosteroid-free remission were included. At diagnosis, patients had undergone ileocolonoscopy to identify active CD lesions, such as ulcers and erosions, and small bowel capsule endoscopy to assess the Lewis Score (LS). After ≥ 1 year of follow-up, patients underwent entire gastrointestinal tract evaluation with PCC2. The primary endpoint was assessment of CD mucosal healing, defined as no active colonic CD lesions and LS < 135.
resultsTwelve patients were included (7 male; mean age: 32 years), and mean follow-up was 38 mo. The majority of patients (83.3%) received immunosuppressive therapy. Three patients (25%) achieved mucosal healing in both the small bowel and the colon, while disease activity was limited to either the small bowel or the colon in 5 patients (42%). It was possible to observe the entire gastrointestinal tract in 10 of the 12 patients (83%) who underwent PCC2.
conclusionOnly three patients in sustained corticosteroid-free clinical remission achieved mucosal healing in both the small bowel and the colon, highlighting the limitations of clinical assessment when stratifying disease activity, and the need for pan-enteric endoscopy to guide therapeutic modification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.