Evidence map›Paper›PMID 26109736›Full record

SynthesisAnnals of the rheumatic diseases2015

Recommendations for the management of autoinflammatory diseases.

Nienke M ter Haar, Marlen Oswald, Jerold Jeyaratnam, Jordi Anton, Karyl S Barron, Paul A Brogan, Luca Cantarini, Caroline Galeotti, Gilles Grateau, Veronique Hentgen and 17 more

Open access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Annals of the rheumatic diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 3 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 3 syntheses or guidelines pooled it, 274 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Concomitant Systemic Autoinflammatory Diseases:Sultan Qaboos University medical journal · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Dermatologic Manifestations of Noninflammasome-Mediated Autoinflammatory Diseases.JID innovations : skin science from molecules to population health · 2023
    Review
  20. Review

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 13 countries.

Nienke M ter HaarLaboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands Department of Paediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Marlen OswaldDivision of Paediatric Rheumatology, University Hospital Tuebingen, Tuebingen, Germany.
Jerold JeyaratnamDepartment of Paediatrics, University Medical Center Utrecht, Utrecht, The Netherlands.
Jordi AntonPaediatric Rheumatology Unit, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
Karyl S BarronDivision of Intramural Research, National Institute of Health, Bethesda, USA.
Paul A BroganDepartment of Rheumatology, UCL Institute of Child Health, London, UK.
Luca CantariniRheumatology Unit, Policlinico Le Scotte, University of Siena, Siena, Italy.
Caroline GaleottiDepartment of Pediatric Rheumatology, Reference Centre for Autoinflammatory Disorders CEREMAI, Bicêtre Hospital, Paris, France.
Gilles GrateauDepartment of Internal Medicine, APHP, Hôpital Tenon, University Pierre-et-Marie-Curie, Paris, France.
Veronique HentgenFrench Reference Centre for Auto-Inflammatory Diseases in Children, Centre Hospitalier de Versailles, Le Chesnay Cedex, France.
Michael HoferDepartment of Paediatrics, University of Lausanne, Lausanne, Switzerland.
Tilmann KallinichDepartment of Paediatric Pneumology and Immunology, Charité University Medicine, Berlin, Germany.
Isabelle Kone-PautDepartment of Paediatric Rheumatology, Reference Centre for Autoinflammatory Disorders CEREMAI, Bicêtre Hospital, University of Paris SUD, Paris, France.
Helen J LachmannNational Amyloidosis Centre, University College London Medical School, London, UK.
Huri OzdoganDivision of Rheumatology, Cerrahpasa Ic Hastaliklari Klinigi, University Istanbul, Istanbul, Turkey.
Seza OzenDepartment of Paediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Ricardo RussoService of Immunology and Rheumatology, Hospital de Pediatría Garrahan, Buenos Aires, Argentina.
Anna SimonDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Yosef UzielDepartment of Paediatrics, Meir Medical Center, Tel-Aviv University, Tel-Aviv, Israel.
Carine WoutersDepartment of Microbiology and Immunology, University Hospital Leuven, Leuven, Belgium.
Brian M FeldmanDivision of Rheumatology, The Hospital for Sick Children, Toronto, Canada.
Sebastiaan J VastertDepartment of Paediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Nico M WulffraatDepartment of Paediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Susanne M BenselerDepartment of Paediatrics, Rheumatology, Alberta Children's Hospital, University of Calgary, Calgary, Canada.
Joost FrenkelDepartment of Paediatrics, University Medical Center Utrecht, Utrecht, The Netherlands.
Marco GattornoDivision of Paediatrics II, G. Gaslini Institute, Genoa, Italy.
Jasmin B Kuemmerle-DeschnerDivision of Paediatric Rheumatology, University Hospital Tuebingen, Tuebingen, Germany.
University Medical Center Utrecht · NLCentre de Référence des Maladies Autoinflammatoires et des Amyloses · FRSTZ eyetrial · DEUniversity College London · GBAlberta Children's Hospital · CACentre Hospitalier de Versailles · FRCharité - Universitätsmedizin Berlin · DEGarrahan Hospital · ARHacettepe University · TRHôpital Tenon · FRHospital for Sick Children · CAHospital Sant Joan de Déu Barcelona · ESIstanbul University · TRIstituto Giannina Gaslini · ITKU Leuven · BENational Institute of Nursing Research · USRadboud University Nijmegen · NLTel Aviv Sourasky Medical Center · ILUniversity of Lausanne · CHUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

: Autoinflammatory diseases are characterised by fever and systemic inflammation, with potentially serious complications. Owing to the rarity of these diseases, evidence-based guidelines are lacking. In 2012, the European project Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate regimens for the management of children and young adults with rheumatic diseases, facilitating the clinical practice of paediatricians and (paediatric) rheumatologists. One of the aims of SHARE was to provide evidence-based recommendations for the management of the autoinflammatory diseases cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) and mevalonate kinase deficiency (MKD). These recommendations were developed using the European League Against Rheumatism standard operating procedure. An expert committee of paediatric and adult rheumatologists was convened. Recommendations derived from the systematic literature review were evaluated by an online survey and subsequently discussed at a consensus meeting using Nominal Group Technique. Recommendations were accepted if more than 80% agreement was reached. In total, four overarching principles, 20 recommendations on therapy and 14 recommendations on monitoring were accepted with ≥80% agreement among the experts. Topics included (but were not limited to) validated disease activity scores, therapy and items to assess in monitoring of a patient. By developing these recommendations, we aim to optimise the management of patients with CAPS, TRAPS and MKD.

Indexed as

Practice Guidelines as TopicConsensusCryopyrin-Associated Periodic SyndromesFeverHereditary Autoinflammatory DiseasesHumansMevalonate Kinase DeficiencyFever SyndromesMultidisciplinary team-careTreatment

Identifiers

PMID26109736
OpenAlexW1895520487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.