ArticleJournal of leukocyte biology2015
Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis.
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Article in Journal of leukocyte biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
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53 citing papers in PubMed, 91 citations in OpenAlex.
- ATGL-mediated lipid droplet lipolysis promotes collective cell migration in Drosophila.Development (Cambridge, England) · 2026Article
- Lipid droplet profiling during neutrophil differentiation by stimulated Raman scattering microscopy.Biotechnology progress · 2026Article
- Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Astrocytic SCAP deletion ameliorates diabetes-associated cognitive impairment by suppressing microglial neuroinflammation and lipid droplet accumulation via the LCN2-24p3R-mTOR axis.Cell death & disease · 2026Article
- Adenovirus phagocytosis by neutrophils triggers a pro-inflammatory response.PLoS pathogens · 2026Article
- cPLAScience advances · 2026Article
- NG-497 Alleviates Microglia-Mediated Neuroinflammation in a MTNR1A-Dependent Manner.Inflammation · 2025Article
- Lipid droplets as cell fate determinants in skeletal muscle.Trends in endocrinology and metabolism: TEM · 2025Review
- Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases.Journal of neuroinflammation · 2025Review
- Not just sugar: metabolic control of neutrophil development and effector functions.Journal of leukocyte biology · 2024Review
- Article
- FOXO3: at the crossroads of metabolic, inflammatory, and tumorigenic remodeling in the colon.American journal of physiology. Gastrointestinal and liver physiology · 2024Review
- Fatty Acids and their Proteins in Adipose Tissue Inflammation.Cell biochemistry and biophysics · 2024Review
- Metabolism: a potential regulator of neutrophil fate.Frontiers in immunology · 2024Review
- Adipose triglyceride lipase promotes prostaglandin-dependent actin remodeling by regulating substrate release from lipid droplets.Development (Cambridge, England) · 2023Article
- Article
- Pharmacological Upregulation of Microglial Lipid Droplet Alleviates Neuroinflammation and Acute Ischemic Brain Injury.Inflammation · 2023Article
- The expanding organelle lipidomes: current knowledge and challenges.Cellular and molecular life sciences : CMLS · 2023Review
- FOXO3 Deficiency in Neutrophils Drives Colonic Inflammation and Tumorigenesis.International journal of molecular sciences · 2023Article
- The emerging role for metabolism in fueling neutrophilic inflammation.Immunological reviews · 2023Review
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Authors and funding
17 authors at 5 institutions in 4 countries.
Stefanie SchlagerInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Madeleine GoeritzerInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Katharina JandlInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Robert FreiInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Nemanja VujicInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Dagmar KolbInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Heimo StrohmaierInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Juliane DorowInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Thomas O EichmannInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Angelika RosenbergerInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Albert WölflerInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Achim LassInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Erin E KershawInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Uta CeglarekInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Andrea DichlbergerInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Akos HeinemannInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Dagmar KratkyInstitutes of *Molecular Biology and Biochemistry and Experimental and Clinical Pharmacology, Center for Medical Research, and Division of Hematology, Medical University of Graz, Graz, Austria; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Institute of Molecular Biosciences, University of Graz, Graz, Austria; **Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; and Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland dagmar.kratky@medunigraz.at.
Medical University of Graz · ATUniversity Hospital Leipzig · DEUniversity of Graz · ATUniversity of Helsinki · FIUniversity of Pittsburgh · US
Funding
Adipose Triglyceride Lipase (ATGL) in Lipotoxicity and The Metabolic SyndromeR01DK090166 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KERSHAW, ERIN E. · 2011 to 2015
$1.7MAustrian Science Fund FWF F 3004Austrian Science Fund FWF P 22832Austrian Science Fund FWF P 25193Austrian Science Fund FWF P 27070Austrian Science Fund FWF W 1226Austrian Science Fund FWF W 1241NIDDK NIH HHS R01 DK090166
Abstract
In humans, mutations in ATGL lead to TG accumulation in LDs of most tissues and cells, including peripheral blood leukocytes. This pathologic condition is called Jordans' anomaly, in which functional consequences have not been investigated. In the present study, we tested the hypothesis that ATGL plays a role in leukocyte LD metabolism and immune cell function. Similar to humans with loss-of-function mutations in ATGL, we found that global and myeloid-specific Atgl(-/-) mice exhibit Jordans' anomaly with increased abundance of intracellular TG-rich LDs in neutrophil granulocytes. In a model of inflammatory peritonitis, lipid accumulation was also observed in monocytes and macrophages but not in eosinophils or lymphocytes. Neutrophils from Atgl(-/-) mice showed enhanced immune responses in vitro, which were more prominent in cells from global compared with myeloid-specific Atgl(-/-) mice. Mechanistically, ATGL(-/-) as well as pharmacological inhibition of ATGL led to an impaired release of lipid mediators from neutrophils. These findings demonstrate that the release of lipid mediators is dependent on the liberation of precursor molecules from the TG-rich pool of LDs by ATGL. Our data provide mechanistic insights into Jordans' anomaly in neutrophils and suggest that ATGL is a potent regulator of immune cell function and inflammatory diseases.
Indexed as
Lipid MetabolismAcyltransferasesAnimalsHumansLipaseLipid DropletsLipid Metabolism DisordersLymphocytesMiceMice, KnockoutMonocytesNeutrophilsPeritonitisAcyltransferasesLipasePNPLA2 protein, mousearachidonic acideicosanoidsinflammatory cellslipolysis
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