ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Slow Spatial Recruitment of Neocortex during Secondarily Generalized Seizures and Its Relation to Surgical Outcome.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early seizure spread and epilepsy surgery: A systematic review.Epilepsia · 2020Pooled it
- AI-Driven Mapping of Seizure Spread Patterns.Annals of neurology · 2026Article
- Stereo-EEG propagating source reconstruction identifies new surgical targets for epilepsy patients.Brain : a journal of neurology · 2025Article
- A Nonlinear Method to Identify Seizure Dynamic Trajectory Based on Variance of Recurrence Rate in Human Epilepsy Patients Using EEG.Journal of medical signals and sensors · 2025Article
- Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy.Annals of clinical and translational neurology · 2024Article
- Focal seizures induce spatiotemporally organized spiking activity in the human cortex.Nature communications · 2024Article
- Intranasal Administration of BDNF Improves Recovery and Promotes Neural Plasticity in a Neonatal Mouse Model of Hypoxic Ischemia.Experimental neurobiology · 2024Article
- Evaluation of Pharmacology and Pathophysiology Knowledge of Epilepsy among Senior Pharmacy Students: A Single Center Experience.Medicina (Kaunas, Lithuania) · 2023Article
- Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges.eLife · 2022Article
- Ictal wavefront propagation in slices and simulations with conductance-based refractory density model.PLoS computational biology · 2022Article
- Multiple mechanisms shape the relationship between pathway and duration of focal seizures.Brain communications · 2022Article
- Simultaneous two-photon imaging of action potentials and subthreshold inputs in vivo.Nature communications · 2021Article
- Travelling waves reveal a dynamic seizure source in human focal epilepsy.Brain : a journal of neurology · 2021Article
- Evidence for spreading seizure as a cause of theta-alpha activity electrographic pattern in stereo-EEG seizure recordings.PLoS computational biology · 2021Article
- Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale.Communications biology · 2021Article
- Domino-like transient dynamics at seizure onset in epilepsy.PLoS computational biology · 2020Article
- Robust dynamic community detection with applications to human brain functional networks.Nature communications · 2020Article
- Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Association of Seizure Spread With Surgical Failure in Epilepsy.JAMA neurology · 2019Article
- Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy.Nature communications · 2018Article
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5 authors.
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Abstract
Understanding the spatiotemporal dynamics of brain activity is crucial for inferring the underlying synaptic and nonsynaptic mechanisms of brain dysfunction. Focal seizures with secondary generalization are traditionally considered to begin in a limited spatial region and spread to connected areas, which can include both pathological and normal brain tissue. The mechanisms underlying this spread are important to our understanding of seizures and to improve therapies for surgical intervention. Here we study the properties of seizure recruitment-how electrical brain activity transitions to large voltage fluctuations characteristic of spike-and-wave seizures. We do so using invasive subdural electrode arrays from a population of 16 patients with pharmacoresistant epilepsy. We find an average delay of ∼30 s for a broad area of cortex (8 × 8 cm) to be recruited into the seizure, at an estimated speed of ∼4 mm/s. The spatiotemporal characteristics of recruitment reveal two categories of patients: one in which seizure recruitment of neighboring cortical regions follows a spatially organized pattern consistent from seizure to seizure, and a second group without consistent spatial organization of activity during recruitment. The consistent, organized recruitment correlates with a more regular, compared with small-world, connectivity pattern in simulation and successful surgical treatment of epilepsy. We propose that an improved understanding of how the seizure recruits brain regions into large amplitude voltage fluctuations provides novel information to improve surgical treatment of epilepsy and highlights the slow spread of massive local activity across a vast extent of cortex during seizure.
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