ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- An ultrastructural map of a spinal sensorimotor circuit reveals the potential of astroglia modulation.Cell reports · 2026Article
- Molecular profiling of adult C. elegans glia across sexes by single-nuclear RNA-seq.Developmental cell · 2025Article
- Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024Review
- GlialProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans.Neurotoxicology · 2024Article
- Optical Imaging Demonstrates Tissue-Specific Metabolic Perturbations in Mblac1 Knockout Mice.IEEE journal of translational engineering in health and medicine · 2024Article
- Analysis of cnidarian Gcm suggests a neuronal origin of glial EAAT1 function.Scientific reports · 2023Article
- Impact of the gut microbiome on nicotine's motivational effects and glial cells in the ventral tegmental area in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Serotonin and dopamine modulate aging in response to food odor and availability.Nature communications · 2022Article
- Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine inMolecular pharmacology · 2022Article
- Inferences of glia-mediated control in Caenorhabditis elegans.Journal of neuroscience research · 2021Article
- Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans.PLoS genetics · 2021Article
- Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling.PLoS genetics · 2021Article
- The Role of CaCells · 2020Review
- Swimming Induced Paralysis to Assess Dopamine Signaling in Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2019Article
- Blockade and reversal of swimming-induced paralysis in C. elegans by the antipsychotic and D2-type dopamine receptor antagonist azaperone.Neurochemistry international · 2019Article
- The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival.Cell · 2018Article
- Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo β-lactamase, MBLAC1.Molecular omics · 2018Article
- Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration.PLoS genetics · 2018Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Glial cells play a critical role in shaping neuronal development, structure, and function. In a screen for Caenorhabditis elegans mutants that display dopamine (DA)-dependent, Swimming-Induced Paralysis (Swip), we identified a novel gene, swip-10, the expression of which in glia is required to support normal swimming behavior. swip-10 mutants display reduced locomotion rates on plates, consistent with our findings of elevated rates of presynaptic DA vesicle fusion using fluorescence recovery after photobleaching. In addition, swip-10 mutants exhibit elevated DA neuron excitability upon contact with food, as detected by in vivo Ca(2+) monitoring, that can be rescued by glial expression of swip-10. Mammalian glia exert powerful control of neuronal excitability via transporter-dependent buffering of extracellular glutamate (Glu). Consistent with this idea, swip-10 paralysis was blunted in mutants deficient in either vesicular Glu release or Glu receptor expression and could be phenocopied by mutations that disrupt the function of plasma membrane Glu transporters, most noticeably glt-1, the ortholog of mammalian astrocytic GLT1 (EAAT2). swip-10 encodes a protein containing a highly conserved metallo-β-lactamase domain, within which our swip-10 mutations are located and where engineered mutations disrupt Swip rescue. Sequence alignments identify the CNS-expressed gene MBLAC1 as a putative mammalian ortholog. Together, our studies provide evidence of a novel pathway in glial cells regulated by swip-10 that limits DA neuron excitability, DA secretion, and DA-dependent behaviors through modulation of Glu signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.