ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 79 citations in OpenAlex.
- Neuroscientific therapies for subjective tinnitus.Journal of Zhejiang University. Science. B · 2026Review
- Activation of the Gamma-Aminobutyric Acid (GABA)ergic Neural Circuit in Salicylate-Induced Tinnitus: the Inferior Colliculus to the Medial Geniculate Body.Clinical and experimental otorhinolaryngology · 2026Article
- Everolimus Attenuates Salicylate-Induced Tinnitus-Like Behavior and Auditory Cortical Hyperexcitability.Drug design, development and therapy · 2026Article
- Theta-Beta/Gamma Coupling Identifies Bothersome Tinnitus Induced by Thalamocortical Dysrhythmia.Brain and behavior · 2025Article
- Sound-evoked plasticity differentiates tinnitus from non-tinnitus mice.Frontiers in neuroscience · 2025Article
- Decoding tinnitus progression: neurochemical shifts in the anterior cingulate cortex revealed by magnetic resonance spectroscopy.Frontiers in neuroscience · 2025Article
- Subcortical auditory system in tinnitus with normal hearing: insights from electrophysiological perspective.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior.Cell & bioscience · 2024Article
- An MR spectroscopy study of temporal areas excluding primary auditory cortex and frontal regions in subjective bilateral and unilateral tinnitus.Scientific reports · 2023Article
- Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.The Journal of physiology · 2023Article
- Lower glutamate and GABA levels in auditory cortex of tinnitus patients: a 2D-JPRESS MR spectroscopy study.Scientific reports · 2022Article
- Vulnerability to chronic stress and the phenotypic heterogeneity of presbycusis with subjective tinnitus.Frontiers in neuroscience · 2022Review
- What's the buzz? The neuroscience and the treatment of tinnitus.Physiological reviews · 2021Review
- Auditory thalamus dysfunction and pathophysiology in tinnitus: a predictive network hypothesis.Brain structure & function · 2021Review
- Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise.Neuron · 2021Article
- Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging.Hearing research · 2021Review
- Pharmacological Evaluation of Drugs in Animal Models of Tinnitus.Current topics in behavioral neurosciences · 2021Review
- Bimodal Auditory Electrical Stimulation for the Treatment of Tinnitus: Preclinical and Clinical Studies.Current topics in behavioral neurosciences · 2021Article
- Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus.PloS one · 2021Article
- Chronic pain as a brain imbalance between pain input and pain suppression.Brain communications · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Accumulating evidence suggests a role for inhibitory neurotransmitter dysfunction in the pathology of tinnitus. Opposing hypotheses proposed either a pathologic decrease or increase of GABAergic inhibition in medial geniculate body (MGB). In thalamus, GABA mediates fast synaptic inhibition via synaptic GABAA receptors (GABAARs) and persistent tonic inhibition via high-affinity extrasynaptic GABAARs. Given that extrasynaptic GABAARs control the firing mode of thalamocortical neurons, we examined tonic GABAAR currents in MGB neurons in vitro, using the following three groups of adult rats: unexposed control (Ctrl); sound exposed with behavioral evidence of tinnitus (Tin); and sound exposed with no behavioral evidence of tinnitus (Non-T). Tonic GABAAR currents were evoked using the selective agonist gaboxadol. Months after a tinnitus-inducing sound exposure, gaboxadol-evoked tonic GABAAR currents showed significant tinnitus-related increases contralateral to the sound exposure. In situ hybridization studies found increased mRNA levels for GABAAR δ-subunits contralateral to the sound exposure. Tin rats showed significant increases in the number of spikes per burst evoked using suprathreshold-injected current steps. In summary, we found little evidence of tinnitus-related decreases in GABAergic neurotransmission. Tinnitus and chronic pain may reflect thalamocortical dysrhythmia, which results from abnormal theta-range resonant interactions between thalamus and cortex, due to neuronal hyperpolarization and the initiation of low-threshold calcium spike bursts (Walton and Llinás, 2010). In agreement with this hypothesis, we found tinnitus-related increases in tonic extrasynaptic GABAAR currents, in action potentials/evoked bursts, and in GABAAR δ-subunit gene expression. These tinnitus-related changes in GABAergic function may be markers for tinnitus pathology in the MGB.
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