ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Norepinephrine Modulates Coding of Complex Vocalizations in the Songbird Auditory Cortex Independent of Local Neuroestrogen Synthesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Dopamine D1Aa and D2a Receptor Expression in the Auditory System of a Vocal Fish.The Journal of comparative neurology · 2026Article
- Auditory Representation of Vocal Signals in a Pallial Cortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Dopamine D1Aa and D2a Receptor Expression in the Auditory System of a Vocal Fish.bioRxiv : the preprint server for biology · 2025Article
- Auditory pallial regulation of the social behavior network.Communications biology · 2024Article
- Listening to your partner: serotonin increases male responsiveness to female vocal signals in mice.Frontiers in human neuroscience · 2023Article
- Neural circuit for social authentication in song learning.Nature communications · 2022Article
- Locus Coeruleus in Non-Mammalian Vertebrates.Brain sciences · 2022Review
- 5-HT1A Receptors Alter Temporal Responses to Broadband Vocalizations in the Mouse Inferior Colliculus Through Response Suppression.Frontiers in neural circuits · 2021Article
- Effect of the Trigeminal Nerve Stimulation on Auditory Event-Related Potentials.Cerebral cortex communications · 2021Article
- Testosterone synthesis in the female songbird brain.Hormones and behavior · 2020Article
- Auditory learning in an operant task with social reinforcement is dependent on neuroestrogen synthesis in the male songbird auditory cortex.Hormones and behavior · 2020Article
- Neuroestrogen synthesis modifies neural representations of learned song without altering vocal imitation in developing songbirds.Scientific reports · 2020Article
- Phasic locus coeruleus activity regulates cortical encoding of salience information.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Familiarity with social sounds alters c-Fos expression in auditory cortex and interacts with estradiol in locus coeruleus.Hearing research · 2018Article
- Developmental auditory exposure shapes responses of catecholaminergic neurons to socially-modulated song.Scientific reports · 2018Article
- Neuroestrogens rapidly shape auditory circuits to support communication learning and perception: Evidence from songbirds.Hormones and behavior · 2018Review
- Relative salience of syllable structure and syllable order in zebra finch song.Animal cognition · 2018Article
- Sound-induced monoaminergic turnover in the auditory forebrain depends on endocrine state in a seasonally-breeding songbird.Journal of neuroendocrinology · 2018Article
- A Membrane G-Protein-Coupled Estrogen Receptor Is Necessary but Not Sufficient for Sex Differences in Zebra Finch Auditory Coding.Endocrinology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The catecholamine norepinephrine plays a significant role in auditory processing. Most studies to date have examined the effects of norepinephrine on the neuronal response to relatively simple stimuli, such as tones and calls. It is less clear how norepinephrine shapes the detection of complex syntactical sounds, as well as the coding properties of sensory neurons. Songbirds provide an opportunity to understand how auditory neurons encode complex, learned vocalizations, and the potential role of norepinephrine in modulating the neuronal computations for acoustic communication. Here, we infused norepinephrine into the zebra finch auditory cortex and performed extracellular recordings to study the modulation of song representations in single neurons. Consistent with its proposed role in enhancing signal detection, norepinephrine decreased spontaneous activity and firing during stimuli, yet it significantly enhanced the auditory signal-to-noise ratio. These effects were all mimicked by clonidine, an α-2 receptor agonist. Moreover, a pattern classifier analysis indicated that norepinephrine enhanced the ability of single neurons to accurately encode complex auditory stimuli. Because neuroestrogens are also known to enhance auditory processing in the songbird brain, we tested the hypothesis that norepinephrine actions depend on local estrogen synthesis. Neither norepinephrine nor adrenergic receptor antagonist infusion into the auditory cortex had detectable effects on local estradiol levels. Moreover, pretreatment with fadrozole, a specific aromatase inhibitor, did not block norepinephrine's neuromodulatory effects. Together, these findings indicate that norepinephrine enhances signal detection and information encoding for complex auditory stimuli by suppressing spontaneous "noise" activity and that these actions are independent of local neuroestrogen synthesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.