ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Complex Effects on In Vivo Visual Responses by Specific Projections from Mouse Cortical Layer 6 to Dorsal Lateral Geniculate Nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- Map of spiking activity underlying change detection in the mouse visual system.bioRxiv : the preprint server for biology · 2025Article
- Corticothalamic modulation of somatosensory thalamic tactile processing.The Journal of physiology · 2025Article
- Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore.Nature communications · 2025Article
- Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period.Frontiers in cellular neuroscience · 2025Article
- Quantitative analyses of how optimally heterogeneous neural codes maximize neural information in jittery transmission environments.Scientific reports · 2024Article
- Local stimulation of pyramidal neurons in deep cortical layers of anesthetized rats enhances cortical visual information processing.Scientific reports · 2024Article
- Decoding dynamic visual scenes across the brain hierarchy.PLoS computational biology · 2024Article
- Article
- Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.bioRxiv : the preprint server for biology · 2024Article
- Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness.Nature communications · 2024Article
- Efficient mapping of the thalamocortical monosynaptic connectivity in vivo by tangential insertions of high-density electrodes in the cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys.Neuroscience bulletin · 2024Article
- Electrophysiological Signatures of Visual Recognition Memory across All Layers of Mouse V1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo.eLife · 2023Article
- Brain State-Dependent Modulation of Thalamic Visual Processing by Cortico-Thalamic Feedback.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cortical feedback modulates distinct critical period development in mouse visual thalamus.iScience · 2023Article
- Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN.eLife · 2022Article
- Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination.Nature communications · 2021Article
- Optogenetic activation of corticogeniculate feedback stabilizes response gain and increases information coding in LGN neurons.Journal of computational neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Understanding the role of corticothalamic projections in shaping visual response properties in the thalamus has been a longstanding challenge in visual neuroscience. Here, we take advantage of the cell-type specificity of a transgenic mouse line, the GN220-Ntsr1 Cre line, to manipulate selectively the activity of a layer 6 (L6) corticogeniculate population while recording visual responses in the dorsal lateral geniculate nucleus (dLGN). Although driving Ntsr1 projection input resulted in reliable reduction in evoked spike count of dLGN neurons, removing these same projections resulted in both increases and decreases in visually evoked spike count. Both increases and decreases are contrast dependent and the sign is consistent over the full range of contrasts. Tuning properties suggest wide convergence of Ntsr1 cells with similar spatial and temporal frequency tuning onto single dLGN cells and we did not find evidence that Ntsr1 cells sharpen spatiotemporal filtering. These nonspecific changes occur independently of changes in burst frequency, indicating that Ntsr1 corticogeniculate activity can result in both net excitation and net inhibition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.