ArticleJournal of immunology (Baltimore, Md. : 1950)2015
TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- TGF-β in chronic kidney disease: a controversy for decades.Frontiers in immunology · 2026Review
- Progress of CCL20-CCR6 in the airways: a promising new therapeutic target.Journal of inflammation (London, England) · 2024Review
- Structural and dynamic properties of eutectic mixtures based on menthol and fatty acids derived from coconut oil: a MD simulation study.Scientific reports · 2022Article
- Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD.Mucosal immunology · 2021Article
- Regulation of barrier immunity and homeostasis by integrin-mediated transforming growth factor β activation.Immunology · 2020Review
- Concepts of GPCR-controlled navigation in the immune system.Immunological reviews · 2019Review
- Kinetics of corneal leukocytes by intravital multiphoton microscopy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells.JCI insight · 2018Article
- New insights in lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- How I manage pulmonary Langerhans cell histiocytosis.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Review
- Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells.International forum of allergy & rhinology · 2017Article
- Lung Dendritic Cells: Shaping Immune Responses throughout Chronic Obstructive Pulmonary Disease Progression.American journal of respiratory cell and molecular biology · 2017Review
- Role of IL-17A in murine models of COPD airway disease.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Dendritic cell migration in health and disease.Nature reviews. Immunology · 2017Review
- Cigarette smoke differentially modulates dendritic cell maturation and function in time.Respiratory research · 2015Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Small airway chronic inflammation is a major pathologic feature of chronic obstructive pulmonary disease (COPD) and is refractory to current treatments. Dendritic cells (DCs) accumulate around small airways in COPD. DCs are critical mediators of Ag surveillance and Ag presentation and amplify adaptive immune responses. How DCs accumulate around airways remains largely unknown. We use 2-photon DC imaging of living murine lung sections to directly visualize the dynamic movement of living DCs around airways in response to either soluble mediators (IL-1β) or environmental stimuli (cigarette smoke or TLR3 ligands) implicated in COPD pathogenesis. We find that DCs accumulate around murine airways primarily by increasing velocity (chemokinesis) rather than directional migration (chemotaxis) in response to all three stimuli. DC accumulation maximally occurs in a specific zone located 26-50 μm from small airways, which overlaps with zones of maximal DC velocity. Our data suggest that increased accumulation of DCs around airways results from increased numbers of highly chemokinetic DCs entering the lung from the circulation with balanced rates of immigration and emigration. Increases in DC accumulation and chemokinesis are partially dependent on ccr6, a crucial DC chemokine receptor, and fibroblast expression of the integrin αvβ8, a critical activator of TGF-β. αvβ8-Mediated TGF-β activation is known to enhance IL-1β-dependent fibroblast expression of the only known endogenous ccr6 chemokine ligand, ccl20. Taken together, these data suggest a mechanism by which αvβ8, ccl20, and ccr6 interact to lead to DC accumulation around airways in response to COPD-relevant stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.