ArticleOncotarget2015
Detecting cell-in-cell structures in human tumor samples by E-cadherin/CD68/CD45 triple staining.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05642104 (The Detection of Cell-in-cell Structure), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Detection of Cell-in-cell Structure (CICs) in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Correlation of Cell-in-Cell Structure With Prognosis in Solid Tumors-A Meta-Analysis.BioMed research international · 2025Pooled it
- Entosis in Health and Disease.Advances in experimental medicine and biology · 2025Review
- Non-Professional Phagocytosis Increases in Melanoma Cells and Tissues with Increasing E-Cadherin Expression.Current oncology (Toronto, Ont.) · 2023Article
- Cell-in-Cell Structures in Gastrointestinal Tumors: Biological Relevance and Clinical Applications.Journal of personalized medicine · 2023Review
- Tumor malignancy by genetic transfer between cells forming cell-in-cell structures.Cell death & disease · 2023Article
- Subtype-based analysis of cell-in-cell structures in non-small cell lung cancer.American journal of cancer research · 2023Article
- Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance.iScience · 2022Article
- Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y.Biology direct · 2022Article
- Cell-in-cell structure mediates in-cell killing suppressed by CD44.Cell discovery · 2022Article
- Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer.Cell death discovery · 2022Article
- Heterotypic neutrophil-in-tumor structure: A novel pathological feature first discovered in the tissues of OPSCC.Frontiers in oncology · 2022Article
- Homotypic cell-in-cell structures as an adverse prognostic predictor of hepatocellular carcinoma.Frontiers in oncology · 2022Article
- Molecular mechanisms underlying cell-in-cell formation: core machineries and beyond.Journal of molecular cell biology · 2021Article
- Subtype-Based Analysis of Cell-in-Cell Structures in Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2021Article
- Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation.BMC molecular and cell biology · 2020Article
- Identification and validation of heterotypic cell-in-cell structure as an adverse prognostic predictor for young patients of resectable pancreatic ductal adenocarcinoma.Signal transduction and targeted therapy · 2020Article
- PCDH7 Inhibits the Formation of Homotypic Cell-in-Cell Structure.Frontiers in cell and developmental biology · 2020Article
- Predictive significance of T cell subset changes duringOncology letters · 2019Article
- Biological relevance of cell-in-cell in cancers.Biochemical Society transactions · 2019Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Cell-in-cell structures (CICs) had been documented in human tumors for decades, it is unclear what types of CICs were formed largely due to low resolution of traditional way such as H&E staining. In this work, we employed immunofluorescent method to stain a panel of human tumor samples simultaneously with antibodies against E-cadherin for Epithelium, CD68 for Macrophage and CD45 for Leukocytes, which we termed as "EML method" based on the cells detected. Detail analysis revealed four types of CICs, with tumor cells or macrophage engulfing tumor cells or leukocytes respectively. Interestingly, tumor cells seem to be dominant over macrophage (93% vs 7%) as the engulfer cells in all CICs detected, whereas the overall amount of internalized tumor cells is comparable to that of internalized CD45+ leukocytes (57% vs 43%). The CICs profiles vary from tumor to tumor, which may indicate different malignant stages and/or inflammatory conditions. Given the potential impacts different types of CICs might have on tumor growth, we therefore recommend EML analysis of tumor samples to clarify the correlation of CICs subtypes with clinical prognosis in future researches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.