ArticleOncotarget2015
Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Biomarker concordance between primary colorectal cancer and its metastases.EBioMedicine · 2019Pooled it
- Article
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.International journal of molecular sciences · 2023Article
- Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development.Communications biology · 2022Article
- Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma.Journal of experimental & clinical cancer research : CR · 2022Article
- Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Discovering Innate Driver Variants for Risk Assessment of Early Colorectal Cancer Metastasis.Frontiers in oncology · 2022Article
- Quadruple-editing of the MAPK and PI3K pathways effectively blocks the progression of KRAS-mutated colorectal cancer cells.Cancer science · 2021Article
- High Concordance of Genomic Profiles between Primary and Metastatic Colorectal Cancer.International journal of molecular sciences · 2021Article
- Targeting BMI-1-mediated epithelial-mesenchymal transition to inhibit colorectal cancer liver metastasis.Acta pharmaceutica Sinica. B · 2021Article
- Prognostic Factors of Colorectal Cancer: A Comparative Study on Patients With or Without Liver Metastasis.Frontiers in oncology · 2021Article
- Article
- Genetic Alterations of Metastatic Colorectal Cancer.Biomedicines · 2020Review
- Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases.Nature genetics · 2020Article
- The Neuropeptide System and Colorectal Cancer Liver Metastases: Mechanisms and Management.International journal of molecular sciences · 2020Review
- Genomic profiles of colorectal carcinoma with liver metastases and newly identified fusion genes.Cancer science · 2019Article
- Estrogen receptor 1 mutations in 260 cervical cancer samples from Chinese patients.Oncology letters · 2019Article
- Quantitative evidence for early metastatic seeding in colorectal cancer.Nature genetics · 2019Article
- Article
- Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer.Nature communications · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To characterize the mutation profiles of colorectal cancer (CRC) primary tumors (PTs) and liver metastases (CLMs), we performed both whole-exome and RNA sequencing. Ten significantly mutated genes, including BMI1, CARD11, and NRG1, were found in 34 CRCs with CLMs. We defined three mutation classes (Class 1 to 3) based on the absence or presence of mutations during liver metastasis. Most mutations were classified into Class 1 (shared between PTs and CLMs), suggesting the common clonal origin of PTs and CLMs. Class 1 was more strongly associated with the clinical characteristics of advanced cancer and was more frequently superimposed with chromosomal deletions in CLMs than Class 2 (PT-specific). The integration of exome and RNA sequencing revealed that variant-allele frequencies (VAFs) of mutations in the transcriptome tended to have stronger functional implications than those in the exome. For instance, VAFs of the TP53 and APC mutations in the transcriptome significantly correlated with the expression level of their target genes. Additionally, mutations with high functional impact were enriched with high VAFs in the CLM transcriptomes. We identified 11 mutation-associated splicing events in the CRC transcriptomes. Thus, the integration of the exome and the transcriptome may elucidate the underlying molecular events responsible for CLMs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.