Evidence map›Paper›PMID 26109356›Full record

ArticleG3 (Bethesda, Md.)2015

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.

Madeline A Crosby, L Sian Gramates, Gilberto Dos Santos, Beverley B Matthews, Susan E St Pierre, Pinglei Zhou, Andrew J Schroeder, Kathleen Falls, David B Emmert, Susan M Russo and 2 more

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Leaky ribosomal scanning enables tunable translation of bicistronic ORFs in green algae.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Widespread polycistronic gene expression in green algae.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Article
  11. UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner.Biochemical and biophysical research communications · 2020
    Article
  12. Article
  13. Review
  14. Review
  15. FlyBase at 25: looking to the future.Nucleic acids research · 2017
    Article
  16. Evolutionary Dynamics of Abundant Stop Codon Readthrough.Molecular biology and evolution · 2016
    Article
  17. Using FlyBase, a Database of Drosophila Genes and Genomes.Methods in molecular biology (Clifton, N.J.) · 2016
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Madeline A CrosbyDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, crosby@morgan.harvard.edu.
L Sian GramatesDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Gilberto Dos SantosDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Beverley B MatthewsDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Susan E St PierreDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Pinglei ZhouDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Andrew J SchroederDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Kathleen FallsDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
David B EmmertDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Susan M RussoDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
William M GelbartDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
FlyBase Consortium

Funding

FLYBASE: A DROSOPHILA RELATIONAL DATABASEP41HG000739 · NHGRI · HARVARD UNIVERSITY · PI GELBART, WILLIAM MARTIN · 1992 to 2014
$56.6M
Resource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3M
Medical Research Council G1000968NHGRI NIH HHS P41 HG000739NHGRI NIH HHS U41 HG000739NHGRI NIH HHS U41 HG00739
6 · The paper itself

Abstract

In the context of the FlyBase annotated gene models in Drosophila melanogaster, we describe the many exceptional cases we have curated from the literature or identified in the course of FlyBase analysis. These range from atypical but common examples such as dicistronic and polycistronic transcripts, noncanonical splices, trans-spliced transcripts, noncanonical translation starts, and stop-codon readthroughs, to single exceptional cases such as ribosomal frameshifting and HAC1-type intron processing. In FlyBase, exceptional genes and transcripts are flagged with Sequence Ontology terms and/or standardized comments. Because some of the rule-benders create problems for handlers of high-throughput data, we discuss plans for flagging these cases in bulk data downloads.

Indexed as

Molecular Sequence AnnotationAnimalsBase SequenceCodon, TerminatorDatabases, GeneticDrosophila melanogasterMitochondriaModels, GeneticProtein BiosynthesisRNA EditingRNA Splice SitesCodon, TerminatorRNA Splice Sitesbicistronicmultiphasic exonnon-AUG translation startshared promoterstop-codon suppression

Identifiers

PMID26109356
PMCPMC4528330

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.