ArticleParasitology research2015
Antimalarial and antioxidant activities of Indigofera oblongifolia on Plasmodium chabaudi-induced spleen tissue injury in mice.
Article in Parasitology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Spleen protective role, Antiplasmodial and Antioxidant activity of Polyalthia longifolia in mice infected with Plasmodium berghei parasite.Veterinary and animal science · 2026Article
- Morphometric analysis and immunobiological investigation ofOpen life sciences · 2025Article
- Exploring the Role of Antioxidants to Combat Oxidative Stress in Malaria Parasites.Current topics in medicinal chemistry · 2022Article
- Hepatoprotective activity ofFrontiers in cellular and infection microbiology · 2022Article
- Treatment ofFrontiers in microbiology · 2022Article
- Biosynthesized nanosilver as anti-oxidant, anti-apoptotic and anti-inflammatory agent againstSaudi journal of biological sciences · 2021Article
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Botanical candidates from Saudi Arabian flora as potential therapeutics forSaudi journal of biological sciences · 2021Review
- Biosynthesized silver nanoparticles regulate the iron status in the spleen of Plasmodium chabaudi-infected mice.Environmental science and pollution research international · 2020Article
- Biosynthesized silver nanoparticles protect against hepatic injury induced by murine blood-stage malaria infection.Environmental science and pollution research international · 2020Article
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- Silver Nanoparticles Biosynthesized WithFrontiers in veterinary science · 2020Article
- Effect ofOxidative medicine and cellular longevity · 2019Article
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- In vivo assessment of the antimalarial and spleen-protective activities of the Saudi propolis methanolic extract.Parasitology research · 2017Article
- Neuroprotective potential ofNeural regeneration research · 2016Article
- Eco-friendly drugs from the marine environment: spongeweed-synthesized silver nanoparticles are highly effective on Plasmodium falciparum and its vector Anopheles stephensi, with little non-target effects on predatory copepods.Environmental science and pollution research international · 2016Article
- Fighting arboviral diseases: low toxicity on mammalian cells, dengue growth inhibition (in vitro), and mosquitocidal activity of Centroceras clavulatum-synthesized silver nanoparticles.Parasitology research · 2016Article
- Antimalarial Properties of Aqueous Crude Extracts ofJournal of tropical medicine · 2016Article
- Indigofera oblongifolia Prevents Lead Acetate-Induced Hepatotoxicity, Oxidative Stress, Fibrosis and Apoptosis in Rats.PloS one · 2016Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria is still one of the most common infectious diseases and leads to various public health problems worldwide. Medicinal plants are promising sources for identifying novel agents with potential antimalarial activity. This study aimed to investigate the antimalarial and the antioxidant activities of Indigofera oblongifolia on Plasmodium chabaudi-induced spleen tissue injury in mice. Mice were divided into five groups. The first group served as a vehicle control; the second, third, fourth, and fifth groups were infected with 1 × 10(6) P. chabaudi-parasitized erythrocytes. Mice of the last three groups were gavaged with 100 μl of I. oblongifolia leave extract (IOLE) at a dose of 100, 200, and 300 mg IOLE/kg, respectively, once daily for 7 days. IOLE was significantly able to lower the percentage of parasitemia. The most effective dose was the 100 mg IOLE/kg, which could reduce the parasitemia from about 38 to 12 %. The infection induced spleen injury. This was evidenced by disorganization of spleen white and red pulps, appearance of hemozoin granules and parasitized erythrocytes. These changes in spleen led to the increased histological score. Also, the infection increased the spleen oxidative damage where the levels of nitrite/nitrate, malondialdehyde, and catalase were significantly altered. All these infection-induced parameters were significantly improved during IOLE treatment. In addition, the mRNA expression of inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha were upregulated after infection with P. chabaudi, whereas IOLE significantly reduced the expression of these genes. Our results indicate that I. oblongifolia leaves extract exhibits a significant antimalarial and antioxidant effects, and protects host spleen tissue from injuries induced by P. chabaudi.
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