ReviewClinical journal of the American Society of Nephrology : CJASN2015
Mild Chronic Hyponatremia in the Ambulatory Setting: Significance and Management.
Review in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04588207 (Urea for Chronic Hyponatremia), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urea for Chronic Hyponatremia: A Pilot Study
Who cites it
20 citing papers in PubMed.
- Reassessing the Role of Copeptin in Emergency Department Admissions for Hypotonic Hyponatremia.The Journal of clinical endocrinology and metabolism · 2025Article
- Syndrome of Inappropriate Antidiuresis: From Pathophysiology to Management.Endocrine reviews · 2023Review
- Hyponatremia and Cancer: From Bedside to Benchside.Cancers · 2023Review
- Korean Society of Nephrology 2022 recommendations on controversial issues in diagnosis and management of hyponatremia.The Korean journal of internal medicine · 2022Review
- Korean Society of Nephrology 2022 Recommendations on controversial issues in diagnosis and management of hyponatremia.Kidney research and clinical practice · 2022Article
- Clinical efficacy of urea treatment in syndrome of inappropriate antidiuretic hormone secretion.Scientific reports · 2022Article
- Korean Society of Nephrology 2022 Recommendations on Controversial Issues in Diagnosis and Management of Hyponatremia.Electrolyte & blood pressure : E & BP · 2022Review
- Article
- Oxcarbazepine and Hyponatremia.Medicina (Kaunas, Lithuania) · 2022Article
- Management of SIADH-related hyponatremia due to psychotropic medications - An expert consensus from the Association of Medicine and Psychiatry.Journal of psychosomatic research · 2021Article
- Hyponatremia and Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Review
- Assocıatıons between mıld hyponatremıa and gerıatrıc syndromes ın outpatıent settıngs.International urology and nephrology · 2021Article
- Issues and Controversies in the Evolution of Oral Rehydration Therapy (ORT).Tropical medicine and infectious disease · 2021Review
- Symptomatology of carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy.Epilepsia · 2021Observational
- Dysnatremias in Chronic Kidney Disease: Pathophysiology, Manifestations, and Treatment.Frontiers in medicine · 2021Review
- [Hyponatremia in older persons (part I)-keep diagnosis simple : How to detect tricks and avoid pitfalls].Zeitschrift fur Gerontologie und Geriatrie · 2020Article
- Omeprazole-induced and pantoprazole-induced asymptomatic hyponatremia: a case report.Journal of medical case reports · 2020Article
- Prevalence of hyponatremia in inpatients with incurable and life-limiting diseases and its association with physical symptoms-a retrospective descriptive study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Vasopressin Receptor Antagonists in Hyponatremia: Uses and Misuses.Frontiers in medicine · 2017Review
- Hyponatremia in solid-tumor cancer patients: uncertainty regarding the use of vaptans.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mild chronic hyponatremia, as defined by a persistent (>72 hours) plasma sodium concentration between 125 and 135 mEq/L without apparent symptoms, is common in ambulatory patients and generally perceived as being inconsequential. The association between increased mortality and hyponatremia in hospitalized patients in various settings and etiologies is widely recognized. This review analyzes the significance of mild chronic hyponatremia in ambulatory subjects and its effects on mortality and morbidity. It addresses whether this disorder should even be treated and if so, which patients are likely to benefit from treatment. The available approaches to correct hyponatremia in such patients in the context of recently published panel-generated recommendations and guidelines are described.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.