Evidence map›Paper›PMID 26108960›Full record

Trial reportJournal of neurophysiology2015

Compensatory stepping in Parkinson's disease is still a problem after deep brain stimulation randomized to STN or GPi.

R J St George, P Carlson-Kuhta, L A King, K J Burchiel, F B Horak

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Interventions for preventing falls in Parkinson's disease.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Unraveling the threads of stability: A review of the neurophysiology of postural control in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Surgical Management of Parkinson's Disease in the Elderly.Movement disorders clinical practice · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

R J St GeorgeDepartment of Neurology, Oregon Health and Science University, Beaverton, Oregon; Human Motor Control Laboratory, School of Medicine, University of Tasmania, Hobart, Australia.
P Carlson-KuhtaDepartment of Neurology, Oregon Health and Science University, Beaverton, Oregon;
L A KingDepartment of Neurology, Oregon Health and Science University, Beaverton, Oregon;
K J BurchielDepartment of Neurosurgery, Oregon Health and Science University, Beaverton, Oregon;
F B HorakDepartment of Neurology, Oregon Health and Science University, Beaverton, Oregon; Department of Veterans Affairs Portland Health Care System, Portland, Oregon; and horakf@ohsu.edu.
Oregon Health & Science University · USVA Portland Health Care System · US

Funding

PERIPHERAL AND CENTRAL POSTURAL DISORDERS IN THE ELDERLYR01AG006457 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HORAK, FAY BAHLING · 1986 to 2018
$5.2M
Peripheral and central Postural Disorders in the ElderlyR37AG006457 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HORAK, FAY BAHLING · 2004 to 2013
$4.5M
EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROLR01AG019706 · NIA · OREGON HEALTH AND SCIENCE UNIVERSITY · PI HORAK, FAY BAHLING · 2001 to 2005
$1.2M
NIA NIH HHS AG-006457NIA NIH HHS AG-19706NIA NIH HHS R01 AG006457
6 · The paper itself

Abstract

The effects of deep brain stimulation (DBS) on balance in people with Parkinson's disease (PD) are not well established. This study examined whether DBS randomized to the subthalamic nucleus (STN; n = 11) or globus pallidus interna (GPi; n = 10) improved compensatory stepping to recover balance after a perturbation. The standing surface translated backward, forcing subjects to take compensatory steps forward. Kinematic and kinetic responses were recorded. PD-DBS subjects were tested off and on their levodopa medication before bilateral DBS surgery and retested 6 mo later off and on DBS, combined with off and on levodopa medication. Responses were compared with PD-control subjects (n = 8) tested over the same timescale and 17 healthy control subjects. Neither DBS nor levodopa improved the stepping response. Compensatory stepping in the best-treated state after surgery (DBS+DOPA) was similar to the best-treated state before surgery (DOPA) for the PD-GPi group and the PD-control group. For the PD-STN group, there were more lateral weight shifts, a delayed foot-off, and a greater number of steps required to recover balance in DBS+DOPA after surgery compared with DOPA before surgery. Within the STN group five subjects who did not fall during the experiment before surgery fell at least once after surgery, whereas the number of falls in the GPi and PD-control groups were unchanged. DBS did not improve the compensatory step response needed to recover from balance perturbations in the GPi group and caused delays in the preparation phase of the step in the STN group.

Indexed as

Postural BalanceWalkingAgedBiomechanical PhenomenaCase-Control StudiesDeep Brain StimulationFemaleGlobus PallidusHumansLevodopaMaleMiddle AgedParkinson DiseaseSubthalamic NucleusLevodopabalancecompensatory steppingdeep brain stimulationParkinson's disease

Identifiers

PMID26108960
PMCPMC4556849
OpenAlexW1877711743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.