ArticleJournal of neurophysiology2015
Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Associations between smooth pursuit, predictive pursuit, anomalous self-experiences, and psychotic-like experiences.European archives of psychiatry and clinical neuroscience · 2026Article
- Computational Characterization of Decision Making During Trans-saccadic Visual Perception.bioRxiv : the preprint server for biology · 2026Article
- Article
- Abnormal Oculomotor Corollary Discharge Signaling as a Trans-diagnostic Mechanism of Psychosis.Schizophrenia bulletin · 2024Article
- Pre-saccadic shifts of attention in individuals diagnosed with schizophrenia.Brain and behavior · 2024Article
- Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition.Nature communications · 2023Article
- Thalamo-cortical circuits during sensory attenuation in emerging psychosis: a combined magnetoencephalography and dynamic causal modelling study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Oculomotor corollary discharge signaling is related to repetitive behavior in children with autism spectrum disorder.Journal of vision · 2021Article
- Article
- Consciousness in active inference: Deep self-models, other minds, and the challenge of psychedelic-induced ego-dissolution.Neuroscience of consciousness · 2021Review
- Prediction, Psychosis, and the Cerebellum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Disrupted Corollary Discharge in Schizophrenia: Evidence From the Oculomotor System.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- A generative learning model for saccade adaptation.PLoS computational biology · 2019Article
- Structural Thalamofrontal Hypoconnectivity Is Related to Oculomotor Corollary Discharge Dysfunction in Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Hallucinations and Strong Priors.Trends in cognitive sciences · 2019Review
- Transsaccadic Perception Deficits in Schizophrenia Reflect the Improper Internal Monitoring of Eye Movement Rather Than Abnormal Sensory Processing.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Oculomotor Prediction: A Window into the Psychotic Mind.Trends in cognitive sciences · 2017Review
- Review of thalamocortical resting-state fMRI studies in schizophrenia.Schizophrenia research · 2017Review
- Saccadic adaptation to a systematically varying disturbance.Journal of neurophysiology · 2016Article
- Quantifying the spatial extent of the corollary discharge benefit to transsaccadic visual perception.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corollary discharge (CD) refers to "copies" of motor signals sent to sensory areas, allowing prediction of future sensory states. They enable the putative mechanisms supporting the distinction between self-generated and externally generated sensations. Accordingly, many authors have suggested that disturbed CD engenders psychotic symptoms of schizophrenia, which are characterized by agency distortions. CD also supports perceived visual stability across saccadic eye movements and is used to predict the postsaccadic retinal coordinates of visual stimuli, a process called remapping. We tested whether schizophrenia patients (SZP) show remapping disturbances as evidenced by systematic transsaccadic mislocalizations of visual targets. SZP and healthy controls (HC) performed a task in which a saccadic target disappeared upon saccade initiation and, after a brief delay, reappeared at a horizontally displaced position. HC judged the direction of this displacement accurately, despite spatial errors in saccade landing site, indicating that their comparison of the actual to predicted postsaccadic target location relied on accurate CD. SZP performed worse and relied more on saccade landing site as a proxy for the presaccadic target, consistent with disturbed CD. This remapping failure was strongest in patients with more severe psychotic symptoms, consistent with the theoretical link between disturbed CD and phenomenological experiences in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.