ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
A high-throughput assay for quantifying appetite and digestive dynamics.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding.Molecular metabolism · 2025Article
- Genotype for hypocretin receptor (hcrtr2) affects appetite in zebrafish.General and comparative endocrinology · 2025Article
- Review
- Effects of different acute stressors on the regulation of appetite genes in the carp (Royal Society open science · 2023Article
- Drugs prescribed for Phelan-McDermid syndrome differentially impact sensory behaviors inF1000Research · 2023Article
- Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish.Nature communications · 2022Article
- Larval Zebrafish as a Model for Mechanistic Discovery in Mental Health.Frontiers in molecular neuroscience · 2022Review
- The Gut-Brain-Microbiome Axis and Its Link to Autism: Emerging Insights and the Potential of Zebrafish Models.Frontiers in cell and developmental biology · 2021Review
- Article
- Probabilistic Models of Larval Zebrafish Behavior Reveal Structure on Many Scales.Current biology : CB · 2020Article
- An interhemispheric neural circuit allowing binocular integration in the optic tectum.Nature communications · 2019Article
- Article
- Pretectal neurons control hunting behaviour.eLife · 2019Article
- Article
- Intestinal dysmotility in a zebrafish (Molecular autism · 2019Article
- High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy.Science advances · 2018Article
- Role of branchiomotor neurons in controlling food intake of zebrafish larvae.Journal of neurogenetics · 2017Article
- Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.ACS chemical biology · 2016Article
- Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics.Diseases (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Food intake and digestion are vital functions, and their dysregulation is fundamental for many human diseases. Current methods do not support their dynamic quantification on large scales in unrestrained vertebrates. Here, we combine an infrared macroscope with fluorescently labeled food to quantify feeding behavior and intestinal nutrient metabolism with high temporal resolution, sensitivity, and throughput in naturally behaving zebrafish larvae. Using this method and rate-based modeling, we demonstrate that zebrafish larvae match nutrient intake to their bodily demand and that larvae adjust their digestion rate, according to the ingested meal size. Such adaptive feedback mechanisms make this model system amenable to identify potential chemical modulators. As proof of concept, we demonstrate that nicotine, l-lysine, ghrelin, and insulin have analogous impact on food intake as in mammals. Consequently, the method presented here will promote large-scale translational research of food intake and digestive function in a naturally behaving vertebrate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.