ArticleBMC cancer2015
LTA + 252A > G polymorphism is associated with risk of nasal NK/T-cell lymphoma in a Chinese population: a case-control study.
Article in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Association of CTLA-4 polymorphisms with hematologic malignancy susceptibility: a meta-analysis.Frontiers in oncology · 2024Pooled it
- The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis.Bioscience reports · 2020Pooled it
- Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6.BMC evolutionary biology · 2019Article
- Association of three promoter polymorphisms in interleukin-10 gene with cancer susceptibility in the Chinese population: a meta-analysis.Oncotarget · 2017Article
- Observational
- Association between the cytotoxic T-lymphocyte antigen 4-318C/T polymorphism and malignant tumor risk.Biomedical reports · 2016Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNasal NK/T-cell lymphoma is a rare type of lymphoma in Caucasian individuals, but is relatively common in Asian populations. Genetic variants in immune and inflammatory response genes may thus be associated with the risk of developing lymphoma. Here, we investigated the association between immuno-modulatory gene polymorphisms and risk for nasal NK/T-cell lymphoma in a Chinese population.
methodsAnalysis of 12 single nucleotide polymorphisms (SNPs) in IL-10, TNF-α, lymphotoxin-α (LTA), and CTLA-4 genes was performed for 125 patients with NK/T-cell lymphoma and 300 healthy controls by PCR-ligase detection reactions.
resultsThe LTA +252 GA + AA genotypes were associated with increased risk for NK/T-cell lymphoma (OR = 2.96, 95 % CI = 1.42-6.19, P = 0.004 for GA + AA genotype). Haplotype C-G-G-A (TNF-α -857, -308, -238 and LTA +252) also conferred an increased risk (OR = 1.52, 95% CI = 1.14-2.06, P = 0.005). Additionally, the LTA +252 GA + AA genotype was associated with an even higher risk in populations positive for Epstein-Barr virus (OR = 5.20, 95% CI = 1.22-23.41, P = 0.03 for the GA + AA genotype).
conclusionsOur data suggest that the LTA +252 A > G polymorphism is associated with the risk of developing NK/T-cell lymphoma, especially for Epstein-Barr virus-positive NK/T-cell lymphoma in the Chinese population.
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