ArticleAnnals of nuclear medicine2015
High metabolic tumor volume and total lesion glycolysis are associated with lateral lymph node metastasis in patients with incidentally detected thyroid carcinoma.
Article in Annals of nuclear medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
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- Scoring system and a simple nomogram for predicting radioiodine refractory differentiated thyroid cancer: a retrospective study.EJNMMI research · 2022Article
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- A cross-scanner and cross-tracer deep learning method for the recovery of standard-dose imaging quality from low-dose PET.European journal of nuclear medicine and molecular imaging · 2022Article
- Radiomics Analysis of [Diagnostics (Basel, Switzerland) · 2022Review
- The Role of Metabolic Volumetric Parameters in Predicting Malignancy in Incidental Thyroid Nodules Detected inMolecular imaging and radionuclide therapy · 2021Article
- Combinative evaluation of primary tumor and lymph nodes to predict pelvic lymphatic metastasis in cervical cancer: an integrated PET-IVIM MRI study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- Predictive Value of [Scientific reports · 2019Article
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- Evaluation of lobar lymph node metastasis in non-small cell lung carcinoma using modified total lesion glycolysis.Journal of thoracic disease · 2018Article
- Early prediction of lenvatinib treatment efficacy by usingBMJ open · 2018Observational
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- Prognostic value ofBrazilian journal of otorhinolaryngologyArticle
- Incidental thyroid carcinomas. A retrospective study.Il Giornale di chirurgiaArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to investigate whether total lesion glycolysis (TLG) and metabolic tumor volume (MTV) measured by ¹⁸F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) could predict the aggressiveness and lymph node metastasis (LNM) in patients with incidentally detected differentiated thyroid carcinoma.
methodsA total 358 patients with focal FDG-avid thyroid incidentaloma during cancer evaluation were enrolled. Among 235 patients in whom fine-needle aspiration biopsy was performed, 51 patients underwent total thyroidectomy with LN dissection. We analyzed the relationship between volume-based parameters and clinicopathologic characteristics.
resultsThe mean age and tumor size were 57.1 ± 11.3 years and 1.15 ± 0.81 cm, respectively. The prevalence of malignancy was 21.7 % (51/235). When SUV(max) > 5.91, MTV2.5 > 2.05 cm³, and TLG2.5 > 9.09 were used as cutoff points, sensitivity, specificity, and area under curve (AUC) for prediction of lateral LNM were 77.9, 69.1 %, 0.716 (P = 0.047), 77.8, 88.1 %, 0.839 (P < 0.001), 77.8, 85.1 %, and 0.815 (P = 0.002), respectively. However, MTV and TLG had no value in prediction of central LNM, extrathyroidal extension, and multifocality. On comparison ROC curve analysis, the MTV and TLG showed the statistical differences for the prediction of lateral LNM compared with SUV(max) (all P's < 0.05).
conclusionsThis study has shown for the first time that volume-based PET functional parameters had a significant value for the prediction of lateral LNM in incidentally detected PTC. These results suggest that higher MTV and TLG can be potential new risk factors for preoperative risk stratification. The usefulness of TLG and MTV in preoperative risk stratification in patients with PTC needs to be confirmed in further large studies.
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