ArticleMolecular biology and evolution2015
Quantitative Mass Spectrometry Reveals Partial Translational Regulation for Dosage Compensation in Chicken.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Hippocampal Gene Expression in Zebra Finches Reveals Sex- and Subregion-Specific Topographies.eNeuro · 2026Article
- Multi-layered dosage compensation of the avian Z chromosome by increased transcriptional burst frequency and elevated translational rates.Nature communications · 2025Article
- Sex Chromosome Dosage Compensation in Insects.Insects · 2025Review
- Sex Chromosome Evolution: Hallmarks and Question Marks.Molecular biology and evolution · 2024Review
- Comparative genomics illuminates karyotype and sex chromosome evolution of sharks.Cell genomics · 2024Article
- Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Comprehensive translational profiling and STE AI uncover rapid control of protein biosynthesis during cell stress.Nucleic acids research · 2024Article
- Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.PLoS genetics · 2023Article
- Recurrent chromosome reshuffling and the evolution of neo-sex chromosomes in parrots.Nature communications · 2022Article
- Blood transcriptome comparison between sexes and their function in 4-week Rhode Island red chickens.Animal cells and systems · 2022Article
- Protein expression reveals a molecular sexual identity of avian primordial germ cells at pre-gonadal stages.Scientific reports · 2021Article
- Do male and female heterogamety really differ in expression regulation? Lack of global dosage balance in pygopodid geckos.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- The avian W chromosome is a refugium for endogenous retroviruses with likely effects on female-biased mutational load and genetic incompatibilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- The Gene Expression Profile of the Song Control Nucleus HVC Shows Sex Specificity, Hormone Responsiveness, and Species Specificity Among Songbirds.Frontiers in neuroscience · 2021Article
- Tissue-specific patterns of regulatory changes underlying gene expression differences amongGenome research · 2020Article
- Sequence Transpositions Restore Genes on the Highly Degenerated W Chromosomes of Songbirds.Genes · 2020Article
- The Female-Specific W Chromosomes of Birds Have Conserved Gene Contents but Are Not Feminized.Genes · 2020Article
- Astrocyte-microglial association and matrix composition are common events in the natural history of primary familial brain calcification.Brain pathology (Zurich, Switzerland) · 2020Article
- Comparative Transcriptomics Analyses across Species, Organs, and Developmental Stages Reveal Functionally Constrained lncRNAs.Molecular biology and evolution · 2020Article
- Regional epigenetic differentiation of the Z Chromosome between sexes in a female heterogametic system.Genome research · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
There is increasing evidence that dosage compensation is not a ubiquitous feature following sex chromosome evolution, especially not in organisms where females are the heterogametic sex, like in birds. Even when it occurs, compensation can be incomplete and limited to dosage-sensitive genes. However, previous work has mainly studied transcriptional regulation of sex-linked genes, which may not reflect expression at the protein level. Here, we used liquid chromatography-tandem mass spectrometry to detect and quantify expressed levels of more than 2,400 proteins in ten different tissues of male and female chicken embryos. For comparison, transcriptome sequencing was performed in the same individuals, five of each sex. The proteomic analysis revealed that dosage compensation was incomplete, with a mean male-to-female (M:F) expression ratio of Z-linked genes of 1.32 across tissues, similar to that at the RNA level (1.29). The mean Z chromosome-to-autosome expression ratio was close to 1 in males and lower than 1 in females, consistent with partly reduced Z chromosome expression in females. Although our results exclude a general mechanism for chromosome-wide dosage compensation at translation, 30% of all proteins encoded from Z-linked genes showed a significant change in the M:F ratio compared with the corresponding ratio at the RNA level. This resulted in a pattern where some genes showed balanced expression between sexes and some close to 2-fold higher expression in males. This suggests that proteomic analyses will be necessary to reveal a more complete picture of gene regulation and sex chromosome evolution.
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