Evidence map›Paper›PMID 26108626›Full record

ArticleProceedings. Biological sciences2015

Expression change in Angiopoietin-1 underlies change in relative brain size in fish.

Yu-Chia Chen, Peter W Harrison, Alexander Kotrschal, Niclas Kolm, Judith E Mank, Pertti Panula

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Yu-Chia ChenNeuroscience Center and Institute of Biomedicine, Anatomy, University of Helsinki, Haartmaninkatu 8, Helsinki 00290, Finland.
Peter W HarrisonDepartment of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.
Alexander KotrschalDepartment of Ecology and Genetics/Animal Ecology, Uppsala University, Norbyvägen 18D, Uppsala 75236, Sweden Department of Zoology/Ethology, Stockholm University, Svante Arrhenius väg 18B, Stockholm 10691, Sweden.
Niclas KolmDepartment of Ecology and Genetics/Animal Ecology, Uppsala University, Norbyvägen 18D, Uppsala 75236, Sweden Department of Zoology/Ethology, Stockholm University, Svante Arrhenius väg 18B, Stockholm 10691, Sweden niclas.kolm@zoologi.su.se.
Judith E MankDepartment of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.
Pertti PanulaNeuroscience Center and Institute of Biomedicine, Anatomy, University of Helsinki, Haartmaninkatu 8, Helsinki 00290, Finland.
University College London · GBUniversity of Helsinki · FIStockholm University · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain size varies substantially across the animal kingdom and is often associated with cognitive ability; however, the genetic architecture underpinning natural variation in these key traits is virtually unknown. In order to identify the genetic architecture and loci underlying variation in brain size, we analysed both coding sequence and expression for all the loci expressed in the telencephalon in replicate populations of guppies (Poecilia reticulata) artificially selected for large and small relative brain size. A single gene, Angiopoietin-1 (Ang-1), a regulator of angiogenesis and suspected driver of neural development, was differentially expressed between large- and small-brain populations. Zebra fish (Danio rerio) morphants showed that mild knock down of Ang-1 produces a small-brained phenotype that could be rescued with Ang-1 mRNA. Translation inhibition of Ang-1 resulted in smaller brains in larvae and increased expression of Notch-1, which regulates differentiation of neural stem cells. In situ analysis of newborn large- and small-brained guppies revealed matching expression patterns of Ang-1 and Notch-1 to those observed in zebrafish larvae. Taken together, our results suggest that the genetic architecture affecting brain size in our population may be surprisingly simple, and Ang-1 may be a potentially important locus in the evolution of vertebrate brain size and cognitive ability.

Indexed as

Gene Expression RegulationAngiopoietin-Like Protein 1Angiopoietin-like ProteinsAngiopoietinsAnimalsBrainFemaleGene Knockdown TechniquesMalePoeciliaZebrafishZebrafish ProteinsAngiopoietin-Like Protein 1Angiopoietin-like ProteinsAngiopoietinsAngptl1 protein, zebrafishZebrafish Proteinsartificial selectionbrain sizegene expressionknock downneuro-transcriptome

Identifiers

PMID26108626
PMCPMC4590489
OpenAlexW1949726102

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.