ArticleGenome biology and evolution2015
Phylogeographic Refinement and Large Scale Genotyping of Human Y Chromosome Haplogroup E Provide New Insights into the Dispersal of Early Pastoralists in the African Continent.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 86 citations in OpenAlex.
- Exploring the Y Chromosomal Ancestry of Modern Panamanians.PloS one · 2015Trial
- Tracing the Uncharted African Diaspora in Southern Brazil: The Genetic Legacies of Resistance in TwoGenes · 2025Article
- The ancestry and geographical origins of St Helena's liberated Africans.American journal of human genetics · 2023Article
- Placing Ancient DNA Sequences into Reference Phylogenies.Molecular biology and evolution · 2022Article
- Social stratification without genetic differentiation at the site of Kulubnarti in Christian Period Nubia.Nature communications · 2021Article
- New insights into the evolution of human Y chromosome palindromes through mutation and gene conversion.Human molecular genetics · 2021Article
- Insights into the Middle Eastern paternal genetic pool in Tunisia: high prevalence of T-M70 haplogroup in an Arab population.Scientific reports · 2021Article
- Searching for the roots of the first free African American community.Scientific reports · 2020Article
- Y Haplogroup Diversity of the Dominican Republic: Reconstructing the Effect of the European Colonization and the Trans-Atlantic Slave Trades.Genome biology and evolution · 2020Article
- Ancient DNA reveals a multistep spread of the first herders into sub-Saharan Africa.Science (New York, N.Y.) · 2019Article
- The genomic history of the Iberian Peninsula over the past 8000 years.Science (New York, N.Y.) · 2019Article
- The role of matrilineality in shaping patterns of Y chromosome and mtDNA sequence variation in southwestern Angola.European journal of human genetics : EJHG · 2019Article
- Genetic structure and sex-biased gene flow in the history of southern African populations.American journal of physical anthropology · 2018Article
- Carriers of mitochondrial DNA macrohaplogroup L3 basal lineages migrated back to Africa from Asia around 70,000 years ago.BMC evolutionary biology · 2018Article
- Whole-Genome-Sequence-Based Haplotypes Reveal Single Origin of the Sickle Allele during the Holocene Wet Phase.American journal of human genetics · 2018Article
- The peopling of the last Green Sahara revealed by high-coverage resequencing of trans-Saharan patrilineages.Genome biology · 2018Article
- Re-analysis of Whole Genome Sequence Data From 279 Ancient Eurasians Reveals Substantial Ancestral Heterogeneity.Frontiers in genetics · 2018Article
- Article
- Whole Y-chromosome sequences reveal an extremely recent origin of the most common North African paternal lineage E-M183 (M81).Scientific reports · 2017Article
- Human ancestry correlates with language and reveals that race is not an objective genomic classifier.Scientific reports · 2017Article
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Authors and funding
16 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haplogroup E, defined by mutation M40, is the most common human Y chromosome clade within Africa. To increase the level of resolution of haplogroup E, we disclosed the phylogenetic relationships among 729 mutations found in 33 haplogroup DE Y-chromosomes sequenced at high coverage in previous studies. Additionally, we dissected the E-M35 subclade by genotyping 62 informative markers in 5,222 samples from 118 worldwide populations. The phylogeny of haplogroup E showed novel features compared with the previous topology, including a new basal dichotomy. Within haplogroup E-M35, we resolved all the previously known polytomies and assigned all the E-M35* chromosomes to five new different clades, all belonging to a newly identified subhaplogroup (E-V1515), which accounts for almost half of the E-M35 chromosomes from the Horn of Africa. Moreover, using a Bayesian phylogeographic analysis and a single nucleotide polymorphism-based approach we localized and dated the origin of this new lineage in the northern part of the Horn, about 12 ka. Time frames, phylogenetic structuring, and sociogeographic distribution of E-V1515 and its subclades are consistent with a multistep demic spread of pastoralism within north-eastern Africa and its subsequent diffusion to subequatorial areas. In addition, our results increase the discriminative power of the E-M35 haplogroup for use in forensic genetics through the identification of new ancestry-informative markers.
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