ArticleBMC biology2015
The role of juvenile hormone and insulin/TOR signaling in the growth of Manduca sexta.
Article in BMC biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Early attainment of 20-hydroxyecdysone threshold shapes mosquito sexual dimorphism in developmental timing.Nature communications · 2025Article
- Lipases are differentially regulated by hormones to maintain free fatty acid homeostasis for insect brain development.BMC biology · 2024Article
- Functional Study of the Role of theInternational journal of molecular sciences · 2024Article
- Target of Rapamycin Drives Unequal Responses to Essential Amino Acid Depletion for Egg Laying inFrontiers in cell and developmental biology · 2022Article
- Control of the insect metamorphic transition by ecdysteroid production and secretion.Current opinion in insect science · 2021Review
- Conventional and Organic Wheat Germ Have Distinct Physiological Effects in the Tobacco Hornworm,Frontiers in insect science · 2021Article
- Signaling Pathways That Regulate the Crustacean Molting Gland.Frontiers in endocrinology · 2021Review
- A New Role for Neuropeptide F Signaling in Controlling Developmental Timing and Body Size inGenetics · 2020Article
- Impacts of Dietary Nutritional Composition on Larval Development and Adult Body Composition in the Yellow Fever Mosquito (Insects · 2020Article
- Divergent mechanisms for regulating growth and development after imaginal disc damage in the tobacco hornworm,The Journal of experimental biology · 2019Article
- Effects of high-fat diet on feeding and performance in the tobacco hornworm, Manduca sexta.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2019Article
- TOR as a Regulatory Target inFrontiers in physiology · 2019Article
- Hormonal signaling cascades required for phototaxis switch in wandering Leptinotarsa decemlineata larvae.PLoS genetics · 2019Article
- Metamorphosis is induced by food absence rather than a critical weight in the solitary bee,Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Insights into How Longicorn Beetle Larvae Determine the Timing of Metamorphosis: Starvation-Induced Mechanism Revisited.PloS one · 2016Article
- Big or fast: two strategies in the developmental control of body size.BMC biology · 2015Article
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn many insect species, fitness trade-offs exist between maximizing body size and developmental speed. Understanding how various species evolve different life history strategies requires knowledge of the physiological mechanisms underlying the regulation of body size and developmental timing. Here the roles of juvenile hormone (JH) and insulin/target of rapamycin (TOR) signaling in the regulation of the final body size were examined in the tobacco hornworm, Manduca sexta.
resultsFeeding rapamycin to wild-type larvae decreased the growth rate but did not alter the peak size of the larvae. In contrast, feeding rapamycin to the JH-deficient black mutant larvae caused the larvae to significantly increase the peak size relative to the DMSO-fed control animals by lengthening the terminal growth period. Furthermore, the critical weight was unaltered by feeding rapamycin, indicating that in Manduca, the critical weight is not influenced by insulin/TOR signaling. In addition, post-critical weight starved black mutant Manduca given rapamycin underwent metamorphosis sooner than those that were fed, mimicking the "bail-out mechanism".
conclusionsOur study demonstrates that JH masks the effects of insulin/TOR signaling in the determination of the final body size and that the critical weights in Drosophila and Manduca rely on distinct mechanisms that reflect different life history strategies. Our study also suggests that TOR signaling lengthens the terminal growth period in Manduca as it does in Drosophila, and that JH levels determine the relative contributions of nutrient- and body size-sensing pathways to metamorphic timing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.