ArticleAlcoholism, clinical and experimental research2015
Effects of Developmental Alcohol Exposure on Potentiation and Depression of Visual Cortex Responses.
Article in Alcoholism, clinical and experimental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Adult Hippocampal Neurogenesis as a Therapeutic Target in Fetal Alcohol Spectrum Disorder.Advances in experimental medicine and biology · 2025Review
- Dynamics of microglia and dendritic spines in early adolescent cortex after developmental alcohol exposure.Developmental neurobiology · 2021Article
- Prenatal Ethanol Exposure and Neocortical Development: A Transgenerational Model of FASD.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Proceedings of the 2017 annual meeting of the Fetal Alcohol Spectrum Disorders study group.Alcohol (Fayetteville, N.Y.) · 2018Article
- Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex.Brain, behavior, and immunity · 2018Article
- The Role of CREB, SRF, and MEF2 in Activity-Dependent Neuronal Plasticity in the Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Effects of Postnatal Enriched Environment in a Model of Parkinson's Disease in Adult Rats.International journal of molecular sciences · 2017Article
- What the Spectrum of Microglial Functions Can Teach us About Fetal Alcohol Spectrum Disorder.Frontiers in synaptic neuroscience · 2017Review
- Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNeuronal plasticity deficits are thought to underlie abnormal neurodevelopment in fetal alcohol spectrum disorders and in animal models of this condition. Previously, we found that alcohol exposure during a period that is similar to the last months of gestation in humans disrupts ocular dominance plasticity (ODP), as measured in superficial cortical layers. We hypothesize that exposure to alcohol can differentially affect the potentiation and depression of responses that are necessary for activity-dependent sprouting and pruning of neuronal networks. ODP is an established paradigm that allows the assessment of activity-dependent depression and potentiation of responses in vivo.
methodsMouse pups were exposed to 3.6 to 5 g/kg of ethanol in saline daily or every other day between postnatal days 4 and 9. Visual cortex plasticity was then assessed during the critical period for ODP using 2 techniques that separately record in layers 4 (visually evoked potentials [VEPs]) and 2/3 (optical imaging of intrinsic signals [OI]).
resultsWe discovered a layer-specific effect of early alcohol exposure. Recording of VEPs from layer 4 showed that while the potentiation component of ODP was disrupted in animals treated with alcohol when compared with saline controls, the depression component of ODP (Dc-ODP) was unaltered. In contrast, OI from layers 2/3 showed that Dc-ODP was markedly disrupted in alcohol-treated animals when compared with controls.
conclusionsCombined with our previous work, these findings strongly suggest that developmental alcohol exposure has a distinct and layer-specific effect on the potentiation and depression of cortical responses after monocular deprivation.
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